Immunotherapy for Basal and Squamous Cell Skin Cancers

The immune system normally helps protect the body against germs, and it can also help destroy cancer cells. Immunotherapy is the use of medicines to stimulate a person’s own immune system to recognize and destroy cancer cells more effectively. It can be used to treat some people with advanced squamous cell skin cancer.

Immune checkpoint inhibitors

An important part of the immune system is its ability to keep itself from attacking normal cells in the body. To do this, it uses “checkpoints”, which are proteins on immune cells that need to be turned on (or off) to start an immune response. 

Cancer cells sometimes take advantage of these checkpoints to avoid being attacked by the immune system. But drugs that target checkpoint proteins, called checkpoint inhibitors, can help restore the immune response against cancer cells.

Cemiplimab (Libtayo)

Cemiplimab (Libtayo) is a drug that targets PD-1, a checkpoint protein on T cells (a specific type of immune system cell) that normally helps keep these cells from attacking other cells in the body. By blocking PD-1, this drug boosts the immune response against cancer cells. It can be used in people with advanced squamous cell skin cancer that cannot be cured with surgery or radiation therapy.  

This drug is given as an intravenous (IV) infusion, typically every 3 weeks.

Common side effects can include: 

  • Feeling tired
  • Diarrhea
  • Skin rash
  • Nausea
  • Constipation
  • Bone or joint pain
  • Loss of appetite

Other, more serious side effects occur less often:

Infusion reactions: Some people might have an infusion reaction while getting this drug. This is like an allergic reaction, and can include fever, chills, flushing of the face, rash, itchy skin, wheezing, and trouble breathing.

Autoimmune reactions: This drug works by basically removing one of the safeguards that keeps the immune system from attacking other parts of the body. This can sometimes lead to serious or even life-threatening problems in the lungs, intestines, liver, hormone-making glands, kidneys, or other organs.

It’s very important to report any new side effects to your health care team right away. If serious side effects do occur, treatment may need to be stopped and you may get high doses of corticosteroids to suppress your immune system.

To learn more about this type of treatment, see Immune Checkpoint Inhibitors to Treat Cancer.

The American Cancer Society medical and editorial content team

Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Last Medical Review: October 2, 2018 Last Revised: October 2, 2018

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