Retinoid Therapy for Neuroblastoma
Retinoids are chemicals that are related to vitamin A. They are known as differentiating agents because they are thought to help some cancer cells mature (differentiate) into normal cells.
In children with high-risk neuroblastoma, treatment with a retinoid called 13-cis-retinoic acid (isotretinoin) reduces the risk of the cancer coming back after high-dose chemotherapy and stem cell transplant. Most doctors now recommend 6 months of 13-cis-retinoic acid after the transplant. This drug is taken as a capsule, twice a day for 2 weeks, followed by 2 weeks off.
Researchers are now trying to develop more effective retinoids and to define the exact role of this approach in treating neuroblastoma.
Possible side effects
The most common side effect of 13-cis-retinoic acid is dry and cracked lips. Dry skin or eyes are also possible, as are nosebleeds, muscle and joint pains, and changes in the nails.
Last Medical Review: March 14, 2014 Last Revised: January 22, 2016
- Neuroblastoma Surgery
- Chemotherapy for Neuroblastoma
- Radiation Therapy for Neuroblastoma
- High-Dose Chemotherapy/Radiation Therapy and Stem Cell Transplant for Neuroblastoma
- Retinoid Therapy for Neuroblastoma
- Immunotherapy for Neuroblastoma
- Treatment of Neuroblastoma by Risk Group
- Emotional and Social Issues in Children With Neuroblastoma