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Immunotherapy is the use of medicines to help a patient’s own immune system recognize and destroy cancer cells more effectively.
Monoclonal antibodies are lab-made versions of immune system proteins that can attach to a specific target on cells in the body. These antibodies can be injected into the blood to seek out and attach to cancer cells.
Many neuroblastoma cells have large amounts of a substance called GD2 on their surfaces. Monoclonal antibodies that attach to GD2 can help the body’s immune system find and destroy these cancer cells.
Dinutuximab can be used to treat children with high-risk neuroblastoma. This monoclonal antibody is used with a drug that triggers the bone marrow to make more immune cells, called GM-CSF, and isotretinoin to help the body’s immune system recognize and destroy neuroblastoma cells. It is currently part of treatment after receiving a stem cell transplant.
New clinical trials are looking at whether giving immunotherapy before transplant is better.
This drug is given as an infusion into a vein (IV) over many hours, for 4 days in a row. This is done about once a month, usually for a total of about 5 cycles of treatment. Other medicines are given before and during each infusion to help with possible side effects such as pain or infusion reactions.
Dinutuximab can cause side effects, some of which can be serious. Possible side effects include:
Other side effects are possible as well. Talk to your child's treatment team to learn more about the possible side effects and what can be done about them.
This monoclonal antibody is given together with the cytokine (immune system hormone) GM-CSF to help the body’s immune system recognize and destroy neuroblastoma cells.
Naxitamab can be used in patients who are at least 1 year old and who have high-risk neuroblastoma that is in their bones or bone marrow and that has come back or started to grow again after initially responding to treatment.
This drug is given as an infusion into a vein (IV) over 30 to 60 minutes on days 1, 3, and 5 of each 4-week cycle. Other medicines are given before and during each infusion to help with possible side effects such as pain or infusion reactions.
Naxitamab can cause side effects, some of which can be serious. Possible side effects include:
Other side effects are possible as well. Talk to your child's treatment team to learn more about the possible side effects and what can be done about them.
Several cancer vaccines are also being studied for use against neuroblastoma. For these vaccines, injections of modified neuroblastoma cells or other substances are given to train the child’s own immune system to attack cancer cells.
CAR T-cell therapy is a promising new way to get a patient's own immune cells, called T cells, to fight cancer by changing them in the lab so they can find and destroy cancer cells. The T cells used in CAR T-cell therapies are removed from the blood and changed in the lab by adding a gene for a lab-made receptor (called a chimeric antigen receptor or CAR), which helps them attack specific cancer cells.
Studies are now testing if CAR T cells that target GD2 (or other substances) on neuroblastoma cells can be helpful in treating this disease. Most of these are clinical trials that are ongoing or in the planning phase.
Several other types of immunotherapy are also being studied for use against targets found on neuroblastoma cells. Many of these are in clinical trials. If you have questions about these or other investigational treatments for neuroblastoma, talk to your child’s cancer care team.
To learn more about how drugs that work on the immune system are used to treat cancer, see Cancer Immunotherapy.
Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).
Dome JS, Rodriguez-Galindo C, Spunt SL, Santana VM. Chapter 92: Pediatric solid tumors. In: Neiderhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, PA. Elsevier; 2020.
National Cancer Institute. Neuroblastoma Treatment (PDQ). 2024. Accessed at https://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq on March 24, 2025.
Navid F, Sondel PM, Barfield R, et al. Phase I trial of a novel anti GD2 monoclonal antibody, Hu14.18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma. J Clin Oncol. 2014: 32;1445-52
Park JR, Hogarty MD, Bagatell R, et al. Chapter 23: Neuroblastoma. In: Blaney SM, Adamson PC, Helman LJ, eds. Pizzo and Poplack’s Principles and Practice of Pediatric Oncology. 8th ed. Philadelphia Pa: Lippincott Williams & Wilkins; 2021.
Shohet JM, Nuchtern JG, Foster JH. Treatment and prognosis of neuroblastoma. UpToDate. 2021. Accessed at https://www.uptodate.com/contents/treatment-and-prognosis-of-neuroblastoma on March 24, 2025.
Pinto NR, Applebaum MA, Volchenboum SL, et al. Advances in risk classification and treatment strategies for neuroblastoma. J Clin Oncol. 2015: 30;3008-3017.
Yu AL, Gilman AL, Ozkaynak MF, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363:1324–1334.
Last Revised: June 26, 2025
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