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Immunotherapy is the use of medicines to help a patient’s own immune system recognize and destroy cancer cells. Several types of immunotherapy are being studied for use against childhood leukemia, and some are now coming into use.
For this treatment, immune cells called T cells are removed from the child’s blood and genetically altered in the lab to have specific receptors (called chimeric antigen receptors, or CARs) on their surface. These receptors can attach to proteins on leukemia cells. The T cells are then multiplied in the lab and given back into the child’s blood, where they can seek out the leukemia cells and attack them.
This is a type of CAR T-cell therapy that targets the CD19 protein on certain leukemia cells. It can be used to treat childhood acute lymphoblastic leukemia (ALL) that has come back after treatment or that is no longer responding to treatment.
To make this treatment, T cells are removed from the child’s blood during a process called leukapheresis. Blood is removed through an IV line and goes into a machine that removes the T cells. The remaining blood then goes back into the body. This typically takes a few hours, and it might need to be repeated. The cells are then frozen and sent to a lab, where they are turned into CAR T cells and are multiplied. This process can take a few weeks.
For the treatment itself, the child typically gets chemotherapy for a few days to help prepare the body. Then the CAR T cells are infused into a vein.
In most children who have had this treatment, the leukemia could no longer be detected within a few months of treatment, although it’s not yet clear if this means that they have been cured.
This treatment can have serious or even life-threatening side effects, which is why it needs to be given in a medical center that is specially trained in its use.
Cytokine release syndrome (CRS): CRS happens when T cells release chemicals (cytokines) that ramp up the immune system. This can happen within a few days to weeks after treatment, and can be life-threatening. Symptoms can include:
Nervous system problems: This drug can have serious effects on the nervous system, which can result in symptoms such as:
Other serious side effects: Other possible side effects can include:
It’s very important to report any side effects to the health care team right away, as there are often medicines that can help treat them.
Antibodies are proteins made by the body’s immune system to help fight infections. Man-made versions of these proteins, called monoclonal antibodies, can be designed to attack a specific target, such as a protein on the surface of leukemia cells.
Blinatumomab is a special kind of monoclonal antibody because it can attach to 2 different proteins at the same time. One part of blinatumomab attaches to the CD19 protein, which is found on B cells. Another part attaches to CD3, a protein found on immune cells called T cells. By binding to both of these proteins, this drug brings the cancer cells and immune cells together, which helps the immune system attack the cancer cells.
This drug is used to treat some types of B-cell ALL, typically after chemotherapy has been used. It is given into a vein (IV) as a continuous infusion over 28 days. This may be repeated after 2 weeks off. Because of certain serious side effects that occur more often during the first few times it is given, the child usually needs stay in the hospital for the first few days of at least the first 2 cycles.
The most common side effects are fever, headache, swelling of the feet and hands, nausea, tremor, rash, constipation, and low blood potassium levels. It can also cause low white blood cell counts, which increase the risk of serious infection.
This drug can also cause nervous system problems, such as seizures, trouble speaking or slurred speech, passing out, confusion, and loss of balance.
Some children might have serious reactions during the infusion (similar to an allergic reaction). Symptoms can include feeling lightheaded or dizzy (due to low blood pressure), headache, nausea, fever or chills, shortness of breath, and/or wheezing. Your child will be given medicines before each infusion to help prevent this.
This monoclonal antibody, which can be used to treat acute myeloid leukemia (AML), works in a different way. It is described in Targeted Therapy Drugs for Childhood Leukemia.
Other types of immunotherapy are also being studied for use against leukemia.
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
Horton TM, Steuber CP. Overview of the treatment of acute lymphoblastic leukemia in children and adolescents. UpToDate. 2018. Accessed at www.uptodate.com/contents/overview-of-the-treatment-of-acute-lymphoblastic-leukemia-in-children-and-adolescents on December 29, 2018.
National Cancer Institute. Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®)–Health Professional Version. Accessed at https://www.cancer.gov/types/leukemia/hp/child-all-treatment-pdq on December 29, 2018.
National Cancer Institute. Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment (PDQ®)–Health Professional Version. Accessed at https://www.cancer.gov/types/leukemia/hp/child-aml-treatment-pdq on December 29, 2018.
Tarlock K, Cooper TM. Acute myeloid leukemia in children and adolescents. UpToDate. 2018. Accessed at www.uptodate.com/contents/acute-myeloid-leukemia-in-children-and-adolescents on December 29, 2018.
Last Revised: February 12, 2019
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