Chemotherapy for Oral Cavity and Oropharyngeal Cancer

Chemotherapy (chemo) is the use of anti-cancer drugs to treat cancer. For oral cavity and oropharyngeal cancers, the drugs are given into a vein or taken by mouth, which allows them to enter the bloodstream and reach cancer that has spread to organs beyond the head and neck. It may be used in several different situations:

  • Chemo (typically combined with radiation therapy) may be used instead of surgery as the main treatment for some cancers.
  • Chemo (combined with radiation therapy) may be given after surgery to try to kill any small deposits of cancer cells that may have been left behind. This is known as adjuvant chemotherapy.
  • Chemo (sometimes with radiation) may be used to try to shrink some larger cancers before surgery. This is called neoadjuvant or induction chemotherapy. In some cases this makes it possible to use less radical surgery and remove less tissue. This can lead to fewer serious side effects from surgery.
  • Chemo (with or without radiation) can be used to treat cancers that are too large or have spread too far to be removed by surgery. The goal is to slow the growth of the cancer for as long as possible and to help relieve any symptoms the cancer is causing.

The chemo drugs used most often for cancers of the oral cavity and oropharynx are:

  • Cisplatin
  • Carboplatin
  • 5-fluorouracil (5-FU)
  • Paclitaxel (Taxol®)
  • Docetaxel (Taxotere®)

Other drugs that are used less often include

  • Methotrexate
  • Ifosfamide (Ifex®)
  • Bleomycin

A chemo drug may be used alone or combined with other drugs. Combining drugs can often shrink tumors more effectively, but will likely cause more side effects. A commonly used combination is cisplatin and 5-FU. This combination is more effective than either drug alone in shrinking cancers of the oral cavity and oropharynx. Another combination often used is cisplatin, 5-FU, plus docetaxel.

Doctors give chemotherapy in cycles, with each period of treatment followed by a rest period to allow the body time to recover. Each chemotherapy cycle typically lasts for a few weeks.

For cancers of the head and neck (such as oral cavity and oropharyngeal cancers), chemo is often given at the same time as radiation (known as chemoradiation). Cisplatin alone is usually the preferred chemo drug when given along with radiation. Some doctors prefer to give the radiation and chemo before surgery. However, the side effects can be severe and may be too much for some patients.

In patients whose cancers are too advanced for surgery but not widespread, chemo and radiation given together might produce a better outcome than radiation alone. But this combined approach can be hard to tolerate, especially for people in poor health.

Possible side effects of chemotherapy

Chemo drugs attack cells that are dividing quickly, which is why they work against cancer cells. But other cells in the body, such as those in the bone marrow, the lining of the mouth and intestines, and the hair follicles are also affected. This can lead to some side effects.

The side effects of chemo depend on the type and dose of drugs given and how long they are taken. These side effects can include:

  • Hair loss
  • Mouth sores
  • Loss of appetite
  • Nausea and vomiting
  • Diarrhea
  • Low blood counts

Chemo can affect the blood-producing cells of the bone marrow, leading to low blood cell counts. This can lead to:

  • Increased chance of infections (due to low white blood cell counts)
  • Easy bruising or bleeding (due to low blood platelet counts)
  • Fatigue (due to low red blood cell counts)

Along with the risks above, some side effects are seen more often with certain chemo drugs. For example, 5-FU often causes diarrhea. This is often treated with drugs like loperamide. Cisplatin, docetaxel, and paclitaxel can cause nerve damage (called neuropathy). This can lead to numbness and tingling in the hands and feet. This often improves once treatment is stopped, but it can last a long time in some people. Cisplatin can also kidney damage. To help prevent this, the patient is given fluid intravenously (IV) before and after each dose.

Although most side effects improve once treatment is stopped, some can last a long time or even be permanent. If your doctor plans treatment with chemo be sure to discuss the drugs that will be used and the possible side effects. Once chemo is started, tell your health care team if you have any side effects. There are ways to prevent or treat many of the side effects of chemo. For example, many good drugs are available to help prevent or treat nausea and vomiting.

More information on chemotherapy can be found in the Chemotherapy section of our website.

The American Cancer Society medical and editorial content team
Our team is made up of doctors and master's-prepared nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Last Medical Review: July 16, 2014 Last Revised: August 8, 2016

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