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Signs and Symptoms of Oral Cavity and Oropharyngeal Cancer
Oral cavity and oropharyngeal cancers might cause a variety of signs and symptoms, depending on where the cancer is located.
Possible signs and symptoms
Oral cavity (mouth) and oropharyngeal (throat) cancers might cause one or more of these signs or symptoms:
- A sore on the lip or in the mouth that doesn't heal
- Pain in the mouth that doesn’t go away
- A lump or thickening in the lips, mouth, or cheek
- A white or red patch on the gums, tongue, tonsil, or lining of the mouth
- A sore throat or a feeling that something is caught in the throat that doesn’t go away
- Trouble chewing or swallowing
- Trouble moving the jaw or tongue
- Numbness of the tongue, lip, or other area of the mouth
- Swelling or pain in the jaw
- Dentures that start to fit poorly or become uncomfortable
- Loosening of teeth or pain around the teeth
- Voice changes
- A lump or mass in the neck or back of the throat
- Weight loss
- Pain in the ear
When to see a doctor
Many of the signs and symptoms of mouth and throat cancers can also be caused by other diseases, or even by other cancers. But if any of these conditions last more than a few weeks, it’s very important to see a doctor or dentist so the cause can be found and treated, if needed.
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- References
Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).
Floros P, Rao A, McCloy RA, Sim HW, Chin VT, Leavers BC, Crawford JA, Gallagher RM. Altered presentation of oropharyngeal cancer, a 6-year review. ANZ J Surg. 2021 Jun;91(6):1240-1245. doi: 10.1111/ans.16537. Epub 2021 Jan 12.
Huber MA, Tantiwongkosi B. Oral and oropharyngeal cancer. Med Clin North Am. 2014 Nov;98(6):1299-321. doi: 10.1016/j.mcna.2014.08.005. Epub 2014 Sep 20.
National Cancer Institute. Physician Data Query (PDQ). Lip and Oral Cavity Cancer Treatment. May 14, 2025. Accessed at https://www.cancer.gov/types/head-and-neck/hp/adult/lip-mouth-treatment-pdq on January 29, 2026.
Last Revised: March 23, 2026
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