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Chemotherapy (chemo) uses anti-cancer drugs that are usually given into a vein (IV) or taken by mouth. These drugs enter the bloodstream and reach almost all areas of the body. However, many chemo drugs aren’t able to enter the brain and reach tumor cells.
For some brain tumors, the drugs can be given directly into the cerebrospinal fluid (CSF, the fluid that bathes the brain and spinal cord), either in the brain or into the spinal canal below the spinal cord. To help with this, a thin tube known as a ventricular access catheter may be inserted through a small hole in the skull and into a ventricle during a minor operation. (See Surgery for Brain and Spinal Cord Tumors in Children.)
In general, chemo is used for faster growing tumors. Some types of brain tumors, such as medulloblastomas, tend to respond well to chemo.
Some of the chemo drugs used to treat children with brain or spinal cord tumors include:
These drugs may be used alone or in various combinations, depending on the type of brain tumor. Doctors give chemo in cycles. Each cycle generally lasts for a few weeks and is followed by a rest period to give the body time to recover.
Chemo drugs can cause side effects. These depend on the type and dose of drugs, and how long treatment lasts. Possible side effects can include:
Some of the most effective drugs against brain tumors tend to have fewer of these side effects than other common chemo drugs, but they can still occur. Most side effects tend to go away once treatment is finished. Your child’s doctor and treating team will watch closely for any side effects. There are often ways to lessen these side effects. For example, drugs can be given to help prevent or reduce nausea and vomiting.
Some chemo drugs can also have other, less common side effects. For example, cisplatin and carboplatin can also cause kidney damage and hearing loss. Your child’s kidney function and hearing will be checked periodically if they are given these drugs.
Be sure to ask your child’s doctor or nurse about medicines to help reduce side effects, and let them know if your child has side effects so they can be managed. In some cases, the doses of the chemo drugs may need to be reduced or treatment may need to be delayed or stopped to prevent the effects from getting worse.
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
Chang SM, Mehta MP, Vogelbaum MA, Taylor MD, Ahluwalia MS. Chapter 97: Neoplasms of the central nervous system. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2015.
Dorsey JF, Hollander AB, Alonso-Basanta M, et al. Chapter 66: Cancer of the central nervous system. In: Abeloff MD, Armitage JO, Niederhuber JE. Kastan MB, McKenna WG, eds. Abeloff’s Clinical Oncology. 5th ed. Philadelphia, Pa: Elsevier; 2014.
Williams D, Parsons IF, Pollack DA. Chapter 26A: Gliomas, Ependymomas, and Other Nonembryonal Tumors of the Central Nervous System. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 7th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2016.
Last Revised: June 20, 2018
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