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For medical questions, we encourage you to review our information with your doctor.
Chemotherapy (chemo) is the use of drugs to treat cancer. The drugs can be injected into a certain part of the body (such as the liver), or they can be injected into a vein (through an IV line) or taken by mouth (as a pill) to reach most of the body, making this treatment very useful for many types of cancer that have spread. Unfortunately, chemo is usually not as helpful for melanoma as it is for some other types of cancer, but it can shrink tumors in some people.
Chemo might be an option if uveal (eye) melanoma has spread to other parts of the body, although other treatments such as immunotherapy or targeted drugs might be tried first. If chemo is an option, the drugs used are generally the same as for melanoma of the skin. For more information, see Chemotherapy for Melanoma Skin Cancer.
For uveal melanoma that has spread to the liver and can't be removed with surgery, your doctor may suggest that you get chemo directly into your liver through a main artery in the liver, called the hepatic artery. An example of chemo that can be given this way is melphalan. This type of treatment, called “liver-directed” treatment, is usually only an option if the cancer affects less than half of the liver and there are no other places of cancer in the body (or if there are, those areas can be treated with either surgery or radiation).
Chemo drugs attack cells that are dividing quickly, which is why they work against cancer cells. But other cells in the body such as those in the bone marrow (where new blood cells are made), the lining of the mouth and intestines, and the hair follicles, also divide quickly. These cells are likely to be affected by chemo, which can lead to side effects.
The side effects of chemo depend on the type and dose of drugs given, how they are given, and the length of time they are taken. The side effects of systemic chemo can include:
These side effects usually go away after treatment is finished. There are often ways to lessen these side effects. For example, there are drugs to help prevent or reduce nausea and vomiting. Some drugs may also have specific side effects not listed above. Be sure to ask your doctor or nurse about medicines to help reduce side effects, and let them know when you do have side effects so they can be managed.
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Finger PT. Chapter 116: Intraocular melanoma. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2015.
Grisanti S, Tura A. Uveal Melanoma. In Scott JF, Gerstenblith MR, eds. Noncutaneous Melanoma [Internet]. Brisbane (AU): Codon Publications; 2018 Mar. Available from: https://www.ncbi.nlm.nih.gov/books/NBK506988/ doi: 10.15586/codon.noncutaneousmelanoma.2018.
Karcioglu ZA, Haik BG. Chapter 67: Eye, orbit, and adnexal structures. In: Niederhuber JE, Armitage JO, Dorshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 5th ed. Philadelphia, Pa. Elsevier: 2014.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Uveal Melanoma. V.1.2018. Accessed at https://www.nccn.org/professionals/physician_gls/pdf/uveal.pdf on August 15, 2018.
Last Revised: August 25, 2023