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Immunotherapy is the use of medicines to help a person’s immune system better recognize and destroy cancer cells. Many types of immunotherapy are being tested in clinical trials, and some might now be used to treat gallbladder cancer.
An important part of the immune system is its ability to keep itself from attacking the body's normal cells. To do this, it uses “checkpoint” proteins on immune cells, which act like switches that need to be turned on (or off) to start an immune response. Cancer cells sometimes use these checkpoints to avoid being attacked by the immune system.
Drugs that target these checkpoints (called immune checkpoint inhibitors) can be used to treat some gallbladder cancers.
Pembrolizumab (Keytruda) is a drug that targets PD-1, a checkpoint protein on immune system cells called T cells. PD-1 normally helps keep T cells from attacking other cells in the body (including some cancer cells). By blocking PD-1, this drug boosts the immune response against cancer cells. This can shrink some tumors or slow their growth.
Pembrolizumab can used along with the chemotherapy drugs gemcitabine and cisplatin to treat gallbladder cancer that can’t be removed by surgery or that has spread to other parts of the body.
Pembrolizumab can also be used by itself to treat some advanced gallbladder cancers, typically after other treatments have been tried, if there are no other good treatment options, and if the cancer cells have any of the following:
Tumor cells can be tested for these changes.
This drug is given as an intravenous (IV) infusion, typically once every 3 or 6 weeks.
Side effects of PD-1 inhibitors can include:
Other, more serious side effects occur less often. These can include:
Infusion reactions: Some people might have an infusion reaction while getting this drug. This is like an allergic reaction, and can include fever, chills, flushing of the face, rash, itchy skin, feeling dizzy, wheezing, and trouble breathing. It’s important to tell your doctor or nurse right away if you have any of these symptoms while getting this drug.
Autoimmune reactions: This drug works by basically removing one of the safeguards on the body’s immune system. Sometimes this causes the immune system to attack other parts of the body, which can cause serious or even life-threatening problems in the lungs, intestines, liver, hormone-making glands, kidneys, skin, or other organs.
It’s very important to report any new side effects to your health care team right away. If you do have a serious side effect, treatment may need to be delayed or stopped, and you may be given high doses of corticosteroids to suppress your immune system.
To learn more about how drugs that work on the immune system are used to treat cancer, see Cancer Immunotherapy.
The American Cancer Society medical and editorial content team
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
Blair AB, Murphy A. Immunotherapy as a treatment for biliary tract cancers: A review of approaches with an eye to the future. Curr Probl Cancer. 2017 Oct [Epub ahead of print].
DeLeon TT, Ahn DH, Bogenberger JM, et al. Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma. Future Oncol. 2018;14(6):553-566.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Hepatobiliary Cancers. v.1.2018. Accessed at https://www.nccn.org/professionals/physician_gls/pdf/hepatobiliary.pdf on March 29, 2018.
Rojas-Sepúlveda , Tittarelli A, Gleisner MA, et al. Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer. Cancer Immunol Immunother. 2018 Mar 29. doi: 10.1007/s00262-018-2157-5. [Epub ahead of print]
Valle JW, Lamarca A, Goyal L, Barriuso J, Zhu AX. New Horizons for Precision Medicine in Biliary Tract Cancers. Cancer Discov. 2017;7(9):943-962.
Zaidi MY, Maithel SK. Updates on gallbladder cancer management. Current Oncology Reports. 2018; 20(21):1-7. [Epub ahead of print]
Last Revised: November 3, 2023
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