Although the small intestine makes up the largest part of the gastrointestinal (GI) tract, small intestine cancers are rare in the United States. In fact, they account for fewer than 1 in 10 cancers of the GI tract, and fewer than 1 in 100 cancers overall.
American Cancer Society. Cancer Facts & Figures 2026. Atlanta: American Cancer Society; 2026.
National Cancer Institute. SEER Cancer Stat Facts: Small Intestine Cancer. Accessed at http://seer.cancer.gov/statfacts/html/smint.html on Dec 10, 2025.
Last Revised: February 19, 2026
American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy.
American Cancer Society Emails
Sign up to stay up-to-date with news, valuable information, and ways to get involved with the American Cancer Society.