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Treating Anal Cancer
After the cancer is found and staged, your cancer care team will talk with you about treatment options. A key goal of treatment is to save the muscles of the anal sphincter so you can control your bowels, and maintain your overall quality of life.
- How is anal cancer treated?
- Treatment of anal cancer, by stage
- Treating HIV-infected patients for anal cancer
- Treating anal melanoma
- Who treats anal cancer?
- Making treatment decisions
- Questions to ask when deciding on a treatment plan
- Questions to ask during treatment for anal cancer
- Help getting through cancer treatment
- Choosing to stop treatment or choosing no treatment at all
- How is anal cancer treated?
- Treatment of anal cancer, by stage
- Treating HIV-infected patients for anal cancer
- Treating anal melanoma
- Who treats anal cancer?
- Making treatment decisions
- Questions to ask when deciding on a treatment plan
- Questions to ask during treatment for anal cancer
- Help getting through cancer treatment
- Choosing to stop treatment or choosing no treatment at all
Your treatment options depend on many factors. The location, type, and stage (extent of spread) of the tumor are important. In choosing your treatment plan, you and your cancer care team will also consider your age, overall health, and personal preferences.
How is anal cancer treated?
There are many ways to treat anal cancer. Often the best approach combines two or more treatments. In the past, surgery was the only way to cure anal cancer, but now most anal cancers are treated with a combination of radiation and chemotherapy. Surgery is often not needed.
Treatment of anal cancer, by stage
The type of treatment your cancer care team will recommend depends on the type of anal cancer, where it is, and how far it has spread (the stage).
Anal canal cancer and perianal cancer, are managed differently. Anal canal cancer is usually linked with HPV and is most often treated with combined chemotherapy and radiation. Surgery is used only if the cancer comes back or doesn’t go away. Perianal cancer, which grows in the skin around the anus, acts more like skin cancer and is often treated with surgery if it’s small and can be removed. Radiation or chemotherapy may be added if the tumor is larger, can’t be fully removed, or comes back.
Because anal canal cancer makes up the majority of anal cancers and is more common than perianal cancer, the treatment of anal canal cancer is given below.
These cancers may or may not have grown into nearby organs or spread to nearby lymph nodes, but they have not spread to distant parts of the body.
The standard treatment for anal cancers that cannot be removed without harming the anal sphincter is external beam radiation therapy (EBRT) combined with chemo, called chemoradiation. In chemoradiation, the two treatments are given over the same time period. The chemo is usually 5-FU or capecitabine with mitomycin. This combination of chemo is typically given during the first week and around the fifth week of treatment. The EBRT is given daily, Monday through Friday, for 5 to 7 weeks.
If the cancer hasn’t gone away completely after chemoradiation , more treatment might be needed. But it's important to know that it may take months to see the full effects of chemoradiation. Because of this, it is important to continue follow-up appointments with your doctors to monitor the cancer with digital rectal examination and anoscopy. Your doctors may watch any remaining cancer for up to 6 months. It may continue to shrink and even go away without more treatment.
If cancer is still found after 6 months, more treatment is often needed. Most of the time, a surgery called an abdominoperineal resection (APR) might be recommended. In certain cases, only a local resection might be needed.
In this stage, the cancer has spread to distant organs. Most often, anal cancer first spreads to the liver, but it can also spread to the lungs, bones, and distant lymph nodes.
These cancers are very unlikely to be cured. Instead, treatment aims to control the disease and relieve symptoms as long as possible. Chemotherapy, sometimes along with immunotherapy, is usually the standard treatment.
Radiation might be used alone for cancer that has spread to the bones, distant lymph nodes, brain, or spinal cord. It is given to patients with metastatic disease to control certain symptoms like pain or bleeding.
Because anal cancers in this stage can be hard to treat, you might also want to think about taking part in a clinical trial of newer treatments.
Cancer is called recurrent when it comes back after treatment. Recurrence can be local (in or near the same place it started) or distant (spread to organs like the lungs or liver).
If cancer returns in the anus or nearby lymph nodes after treatment, further treatment will depend on what you had the first time. For example, if you only had surgery, you might get chemo with radiation (chemoradiation) or chemo with immunotherapy. If you first had chemoradiation, then you might be treated with surgery and/or chemo. Treating recurrent anal cancer may require a surgery called an abdominoperineal resection (APR).
.The most common sites of anal cancer recurrence or metastasis are the liver and lungs. The main treatment is usually chemo with or without immunotherapy. In other cases, surgery or radiation therapy might be options to help treat these cancers. These treatments are unlikely to cure the cancer, but it can often help control it and reduce symptoms that the cancer may be causing.
Clinical trials of newer treatments might also be useful for people with recurrent anal cancer.
Treating HIV-infected patients for anal cancer
Most people with HIV infection can be given the same treatment as others with anal cancer, and they can have a good prognosis. People with advanced HIV disease and weakened immune systems might need less intensive chemotherapy.
Treating anal melanoma
Melanoma doesn’t respond well to chemotherapy or radiation, so surgery is the main treatment when possible. Early-stage anal melanomas are treated with surgery to remove the tumor and surrounding normal tissue (local excision). If the tumor is large or has grown into deeper tissues such as the sphincter muscle , an abdominoperineal resection (APR) might be needed.
If anal melanoma has spread to other organs, it's treated like skin melanoma that has spread, often with immunotherapy or targeted therapy drugs.
Learn more: Treating Melanoma Skin Cancer.
Who treats anal cancer?
Based on your treatment options, you might have different types of doctors on your treatment team. These doctors could include:
- A radiation oncologist: a doctor who treats cancer with radiation therapy
- A medical oncologist: a doctor who treats cancer with medicines such as chemotherapy and immunotherapy
- A surgical oncologist: a doctor who uses surgery to treat cancer
You might have many other specialists on your treatment team as well, including physician assistants, nurse practitioners, nurses, nutrition specialists, social workers, and other health professionals.
Learn more: Who is the Cancer Care Team?
Making treatment decisions
Your treatment plan will depend on many factors, including your overall health, personal preferences, and whether you plan to have children. Age alone isn’t a reason to avoid treatment—older people often tolerate ovarian cancer treatment well.
Talk with your cancer care team about all your treatment options, their goals, and possible side effects. Ask questions if there's anything you’re not sure about.
Questions to ask when deciding on a treatment plan
- How much experience do you have treating this type of cancer?
- Should I get a second opinion? How do I do that? Can you recommend someone or a cancer center?
- How quickly do I need to decide on treatment?
- What are my treatment choices?
- What treatment would you recommend for me? Why?
- What is the goal of each treatment?
- What should I do to be ready for treatment?
- What are the chances my cancer can be cured with these options?
- How long will treatment last? What will it be like? Where will it be done?
- What are the risks or side effects of the treatments you suggest? How long are they likely to last?
- How soon do I need to start treatment?
- Will treatment affect my daily activities?
Questions to ask during treatment for anal cancer
- How will we know if the treatment is working?
- Is there anything I can do to help manage side effects?
- What symptoms or side effects should I tell you about right away?
- How can I reach you on nights, holidays, or weekends?
- Do I need to change what I eat during treatment?
Other things to consider
- If time allows, consider getting a second opinion to feel more confident about the treatment plan you choose.
- Clinical trials study new treatments and may offer access to promising options not widely available. They are also how doctors learn better ways to treat cancer. Ask your doctor about clinical trials you may qualify for.
- You may hear about ways to relieve symptoms or treat your cancer such as herbs, diets, acupuncture, massage, or many others. Integrative (holistic) methods are used with standard care, while alternative ones replace it. Some may help with symptoms, but many aren’t proven to work and could even be harmful. Talk with your care team first to make sure they’re safe and won’t interfere with treatment.
Help getting through cancer treatment
People with cancer need support and information, no matter what stage of illness they may be in. Knowing all of your options and finding the resources you need will help you make informed decisions about your care.
Whether you are thinking about treatment, getting treatment, or not being treated at all, you can still get supportive care to help with pain or other symptoms. Communicating with your cancer care team is important so you understand your diagnosis, what treatment is recommended, and ways to maintain or improve your quality of life.
Different types of programs and support services may be helpful, and they can be an important part of your care. These might include nursing or social work services, financial aid, nutritional advice, rehab, or spiritual help.
The American Cancer Society also has programs and services - including rides to treatment, lodging, and more - to help you get through treatment. Contact the ACS cancer helpline for more information.
Choosing to stop treatment or choosing no treatment at all
For some people, when treatments have been tried and are no longer controlling the cancer, it could be time to weigh the benefits and risks of continuing to try new treatments. Whether or not you continue treatment, there are still things you can do to help maintain or improve your quality of life.
Some people, especially if the cancer is advanced, might not want to be treated at all. There are many reasons you might decide not to get cancer treatment, but it’s important to talk to your doctors as you make that decision. Remember that even if you choose not to treat the cancer, you can still get care to help with pain or other symptoms.
People who have advanced cancer and who are expected to live less than 6 months may want to consider hospice care. Hospice care is designed to provide the best possible quality of life for people who are near the end of life. You and your family are encouraged to talk with your doctor or a member of your supportive care team about hospice care options, which include hospice care at home, a special hospice center, or other health care locations. Nursing care and special equipment can make staying at home a workable option for many families.
The treatment information given here is not official policy of the American Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. It is intended to help you and your family make informed decisions, together with your doctor. Your doctor may have reasons for suggesting a treatment plan different from these general treatment options. Don't hesitate to ask your cancer care team any questions you may have about your treatment options.
- Written by
- References
Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).
Czito BG, Ahmed S, Kalady MF, and Eng C. Chapter 64: Cancer of the anal region. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles & Practice of Oncology. 11th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2019.
Goodman KA, Kachnic LA, Czito BG. Chapter 76: Cancer of the anal canal. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, Pa. Elsevier: 2020.
Hagemans JAW, Blinde SE, Nuyttens JJ, Morshuis WG, Mureau MAM, Rothbarth J, Verhoef C, Burger JWA. Salvage Abdominoperineal Resection for Squamous Cell Anal Cancer: A 30-Year Single-Institution Experience. Ann Surg Oncol. 2018 Jul;25(7):1970-1979. doi: 10.1245/s10434-018-6483-9. Epub 2018 Apr 24.
Littlejohn JB, Brister KA. Management of Recurrent Anal Cancer. Surg Oncol Clin N Am. 2025 Jan;34(1):91-101. doi: 10.1016/j.soc.2024.07.005. Epub 2024 Oct 24.
National Cancer Institute Physician Data Query (PDQ). Anal Cancer Treatment. Updated May 16,2025. Accessed at https://www.cancer.gov/types/anal/patient/anal-treatment-pdq#_1 on August 20,2025.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Anal Carcinoma. V.4.2025. Accessed at www.nccn.org/professionals/physician_gls/pdf/anal.pdf on August 20, 2025.
Last Revised: November 20, 2025
American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy.
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