Chemotherapy for Merkel Cell Carcinoma

Chemotherapy (chemo) uses anti-cancer drugs that are typically injected into a vein or given by mouth. These drugs travel through the bloodstream to all parts of the body, which makes chemo useful for treating cancers that have spread to other organs.

When might chemo be used?

Merkel cell carcinoma (MCC) is not common, so it’s been hard to study the use of chemotherapy for MCC in clinical trials.

Chemo is most likely to be helpful for MCC that has spread to other organs. So far it’s not clear if it can be helpful for cancers that are still just in the skin or that have only spread to nearby lymph nodes, but some doctors might still recommend it for these cancers (see “Intralesional chemotherapy” below for an example).

Which chemo drugs are used to treat MCC?

It has also been hard to study which chemo drugs work best against MCC. Because of this, doctors often use chemo drugs that are helpful against other types of fast-growing neuroendocrine tumors. The most commonly used drugs for MCCs that have spread include:

  • Cisplatin
  • Carboplatin
  • Etoposide
  • Topotecan

Most often, either cisplatin or carboplatin is used, often along with etoposide. Topotecan tends to have fewer serious side effects, so it might be a better option for some people who are older or have serious health problems.

These drugs are given intravenously (IV or into a vein), usually once every few weeks. They can often shrink MCC tumors for a time (or at least slow their growth and spread) and help relieve some symptoms. But usually these cancers will start growing again.

Intralesional chemotherapy: For some early skin tumors, some doctors have tried injecting small amounts of a chemo drug such as bleomycin directly into the site of the tumor, sometimes after surgery. This seems to help some people, although it hasn’t been studied enough to be sure. One advantage of this approach is that it’s unlikely to cause the side effects often seen with chemo that goes through the whole body.

Possible side effects of chemotherapy

Chemo drugs can cause side effects. These depend on the type and dose of the drugs given and how long they are used. Side effects can include:

These side effects usually go away once treatment is finished. Some drugs can have other effects that are not listed above, so be sure to talk with your cancer care team about what to expect.

There are often ways to lessen these side effects. For example, drugs can help prevent or reduce nausea and vomiting. Tell your cancer care team about any side effects or changes you notice while getting chemo so they can be treated promptly.

To learn more, see the Chemotherapy section of our website.

The American Cancer Society medical and editorial content team
Our team is made up of doctors and master's-prepared nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Last Medical Review: April 13, 2015 Last Revised: May 23, 2016

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