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Can Merkel Cell Carcinoma Be Found Early?

Merkel cell carcinoma (MCC) and many other skin cancers often can be found early, when they're small, haven't spread, and are likely to be easier to treat.

Skin self-exam

The American Cancer Society doesn't have guidelines for the early detection of skin cancer, but knowing how your own skin usually looks is important in finding skin cancer early. Learn the patterns of moles, blemishes, freckles, and other marks on your skin so that you’ll notice any changes.

Many doctors recommend checking your own skin once a month. Skin self-exams are best done in a well-lit room in front of a full-length mirror. Use a hand-held mirror for areas that are hard to see, such as the backs of your thighs.

Examine your skin, including the palms of your hands and soles of your feet, as well as your scalp, ears, nails, and your back. A spouse, partner, or close friend or family member can also help you with these exams, especially for those hard-to-see places, like your scalp and back.

To learn more about how to examine your skin, see How to Do a Skin Self-exam.

When to see a doctor

Any spots on your skin that are new or changing in size, shape, or color should be seen by a doctor right away. If you can’t see your doctor soon, you might want to take good close-up photos of the area so your doctor can see if it's changing when you do get an appointment.

Any unusual sore, lump, blemish, marking, or change in the way an area of the skin looks or feels may be a sign of skin cancer or a warning that it might occur. The area might become red, swollen, scaly, crusty, or start oozing or bleeding. It may feel itchy, tender, or painful.

Merkel cell cancers usually look like firm, pink, red, or purple lumps or bumps on sun-exposed areas of the skin. They usually don't hurt, but they can grow quickly and can sometimes open up as ulcers or sores. (See Signs and Symptoms of Merkel Cell Carcinoma.)

Some doctors and other health care professionals also might examine your skin as part of your routine health check-ups.

Having regular skin exams is especially important for people who are at high risk of Merkel cell cancers or other skin cancers, such as people with weakened immune systems (like those who have had an organ transplant). Talk to your doctor about your skin cancer risk and how often you should have your skin examined.

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Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

National Cancer Institute. Merkel Cell Carcinoma Treatment (PDQ)–Health Professional Version. 2024. Accessed at https://www.cancer.gov/types/skin/hp/merkel-cell-treatment-pdq on November 18, 2024.

Tai P, Nghiem PT, Park SY. Pathogenesis, clinical features, and diagnosis of Merkel cell (neuroendocrine) carcinoma. UpToDate. 2024. Accessed at https://www.uptodate.com/contents/pathogenesis-clinical-features-and-diagnosis-of-merkel-cell-neuroendocrine-carcinoma on November 18, 2024.

Xu YG, Aylward JL, Swanson AM, et al. Chapter 67: Nonmelanoma Skin Cancers. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, Pa. Elsevier: 2019.

Last Revised: January 10, 2025

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