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Cancer starts when cells in the body begin to grow out of control. Cells in nearly any part of the body can become cancer, and can then spread to other areas of the body. To learn more about cancer and how it starts and spreads, see What Is Cancer?
Ewing tumors (also known as Ewing sarcomas) are a group of cancers that start in the bones or nearby soft tissues and share some common features. These tumors can develop in people of any age, but they are most common in older children and teens. For information about the differences between childhood cancers and adult cancers, see Cancer in Children.
The main types of Ewing tumors are:
Researchers have found that the cells that make up Ewing sarcoma, EOE, and PPNET are very similar. They tend to have the same DNA (gene) abnormalities and share similar proteins, which are rarely found in other types of cancers. That’s why these cancers are thought to develop from the same type of cells in the body. There are slight differences among these tumors, but they're all treated the same way.
Most Ewing tumors occur in the bones. The most common sites are:
In contrast, osteosarcoma usually occurs at the ends of the bones of the legs or arms, especially around the knees. Extraosseous Ewing tumors can occur almost anywhere.
Most Ewing tumors occur in children and teens, but they can also occur in adults. This information focuses on the Ewing family of tumors in children and teens, but most of the content here (including much of the treatment information) applies to Ewing tumors in adults as well.
Several other types of cancers can start in the bones.
Osteosarcomas are the most common bone cancer in children and teens. They are described in Osteosarcoma.
Most other types of bone cancers are usually found in adults and are uncommon in children. These include:
For more information on these cancers, see Bone Cancer in Adults.
Many types of cancer that start in other organs of the body can spread to the bones. These are sometimes referred to as metastatic bone cancers, but they are not true bone cancers. For example, if a rhabdomyosarcoma (a cancer that starts in muscle cells) spreads to the bones, it is still rhabdomyosarcoma and is treated like rhabdomyosarcoma. For more information, see Bone Metastases.
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
Anderson ME, Dubois SG, Gebhart MC. Chapter 89: Sarcomas of bone. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, Pa: Elsevier; 2020.
DeLaney TF, Hornicek FJ. Clinical presentation, staging, and prognostic factors of the Ewing sarcoma family of tumors . UpToDate. Accessed at https://www.uptodate.com/contents/clinical-presentation-staging-and-prognostic-factors-of-the-ewing-sarcoma-family-of-tumors on April 14, 2021.
DeLaney TF, Hornicek FJ, Bahrami A. Epidemiology, pathology and molecular genetics of the Ewing sarcoma family of tumors. UpToDate. Accessed at www.uptodate.com/contents/epidemiology-pathology-and-molecular-genetics-of-the-ewing-sarcoma-family-of-tumors on April 14, 2021.
National Cancer Institute. Ewing Sarcoma Treatment (PDQ). 2020. Accessed at https://www.cancer.gov/types/bone/hp/ewing-treatment-pdq on October 29, 2020.
Last Revised: May 25, 2021