When your breast was biopsied, the samples taken were studied under the microscope by a specialized doctor with many years of training called a pathologist. The pathologist sends your doctor a report that gives a diagnosis for each sample taken. Information in this report will be used to help manage your care. The questions and answers that follow are meant to help you understand medical language you might find in the pathology report from a breast biopsy, such as a needle biopsy or an excision biopsy.
In a needle biopsy, a needle is used to remove a sample of an abnormal area. An excision biopsy removes the entire abnormal area, often with some of the surrounding normal tissue. An excision biopsy is much like a type of breast conserving surgery called a lumpectomy.
What is carcinoma?
This is a term used to describe a cancer that begins in the lining layer (epithelial cells) of organs like the breast. Nearly all breast cancers are carcinomas.
What is in-situ carcinoma of the breast?
This term is used for the earliest stage of breast cancer, when it is confined to the layer of cells where it began. The normal breast is made of ducts that end in a group of blind-ending sacs (lobules). Cancer starts in the cells lining the ducts and lobules, when a normal cell becomes a carcinoma cell. As long as the carcinoma cells are still confined to the breast ducts or lobules, and do not break out and grow into surrounding tissue, it is considered in-situ carcinoma. Once the carcinoma cells have grown and broken out of the ducts or lobules, it is called invasive or infiltrating carcinoma. In an invasive carcinoma, the tumor cells can spread (metastasize) to other parts of your body.
What does it mean if my in-situ carcinoma is called ductal carcinoma in-situ, intraductal carcinoma, or in-situ carcinoma with duct and lobular features?
There are 2 main types of in-situ carcinoma of the breast: ductal carcinoma in-situ (DCIS) and lobular carcinoma in situ (LCIS). Intraductal carcinoma is another name for ductal carcinoma in-situ.
Sometimes DCIS and LCIS are both found in the same biopsy.
In-situ carcinoma with duct and lobular features means that the in-situ carcinoma looks like DCIS in some ways and LCIS in some ways (when looked at under the microscope), and so the pathologist can’t call it one or the other.
If left untreated, DCIS can go on to become an invasive cancer, and so it is often called a pre-cancer. Still, we don’t really understand it well. We don’t think that all DCIS would go on to become invasive cancer, but we can’t tell which DCIS would be safe to leave untreated. Treatment is aimed at getting rid of all the DCIS, usually by surgery. In some cases, radiation (radiotherapy) or hormone therapy (like tamoxifen) is given after surgery to lower the chance that it will come back later (recur) or invasive carcinoma will occur. Information about treatment of DCIS can be found in Breast Cancer.
What does it mean if my report mentions E-cadherin?
E-cadherin is a test that the pathologist uses to help determine if the carcinoma in-situ is ductal or lobular. If your report does not mention E-cadherin, it means that this test was not necessary to make the distinction.
What does it mean if my report describes my ductal carcinoma in-situ as being cribriform, micropapillary, apocrine, comedo, with comedonecrosis, papillary, or solid?
These terms are used to describe certain ways that the DCIS looks under the microscope. Some of these are linked to a higher chance that the DCIS may come back after treatment and so finding them may change your treatment.
What does it mean if my ductal carcinoma in-situ is described as being low grade, intermediate grade, or high grade; or nuclear grade 1, nuclear grade 2, or nuclear grade 3; or low mitotic rate, intermediate mitotic rate, or high mitotic rate?
These are all different ways of describing how the DCIS looks under the microscope. When DCIS is high grade, is nuclear grade 3, or has a high mitotic rate, it is more likely to come back (recur) after it is removed completely with surgery as compared to DCIS that is low grade, is nuclear grade 1, or has a low mitotic rate. Patients with higher grade DCIS may need additional treatment.
What is the significance of the reported size of the ductal carcinoma in-situ (DCIS)?
If the entire tumor or area of DCIS is removed (such as in an excision biopsy or breast-conserving surgery), the pathologist will say how big the DCIS is by measuring how long it is across (in greatest dimension), either by looking at it under the microscope or by gross examination (just looking at it with the naked eye if it is big enough). Another way to measure DCIS is to note the number of microscopic slides that contain DCIS, so, for example the report may say that DCIS was found in 3 slides.
On needle biopsy, measurements of the area of DCIS are not often reported because this type of biopsy only samples a part of the tumor. Later, when the entire area of DCIS is removed (with surgery), an accurate measurement can be done.
The larger the area of DCIS, the more likely it is to come back (recur) after surgery. Doctors use information about the size of the DCIS when recommending treatments.
What does it mean if my report mentions special studies such as high molecular weight cytokeratin (HMWCK), CK903, CK5/6, p63, muscle specific actin, smooth muscle myosin heavy chain, calponin, or keratin?
These are special tests that the pathologist sometimes uses to help make the diagnosis of ductal carcinoma in-situ. Not all cases need these tests. Whether your report does or does not mention these tests has no bearing on the accuracy of your diagnosis.
What does it mean if my report on ductal carcinoma in-situ (DCIS) mentions estrogen receptor (ER) or progesterone receptor (PR)?
ER and PR are special tests that the pathologist does that are important in predicting response of the DCIS to hormone therapy (like tamoxifen). Results for ER and PR are reported separately and can be reported in different ways:
- Negative, weakly positive, positive;
- Percent positive; or
- Percent positive with something saying whether the staining is weak, moderate, or strong.
Ask your doctor how these results will affect your treatment.
What if my report on ductal carcinoma in-situ (DCIS) mentions margins or ink?
When the entire area of DCIS is removed, the outside surface (edges) of the specimen is coated with ink, sometimes even with different colors of ink on different sides of the specimen. The pathologist looks at slides of the DCIS under the microscope to see how close the DCIS cells get to the ink (or edges of the specimen). If DCIS is touching the ink (called positive margins), it can mean that some carcinoma cells were left behind, and more surgery or other treatments may be needed. Sometimes, though, the surgeon has already removed more tissue (at surgery) to help make sure that this isn’t needed. If your pathology report shows DCIS with positive margins, your doctor will talk to you about what treatment is best.
What does it mean if my report also mentions atypical ductal hyperplasia (ADH) or atypical lobular hyperplasia (ALH)?
These are less serious than ductal carcinoma in-situ, and you should talk with your doctor about what these findings may mean to your care.
What does it mean if my report also says any of the following terms: usual duct hyperplasia, adenosis, sclerosing adenosis, radial scar, complex sclerosing lesion, papillomatosis, papilloma, apocrine metaplasia, cysts, columnar cell change, collagenous spherulosis, duct ectasia, fibrocystic changes, flat epithelial atypia, or columnar cell change with prominent apical snouts and secretions (CAPSS)?
All of these are terms for benign (non-cancerous changes) that the pathologist sees under the microscope and are not important when seen on a biopsy where there is ductal carcinoma in-situ.
What does it mean if my report mentions microcalcifications or calcifications?
Microcalcifications or calcifications are mineral deposits that can be found in both non-cancerous and cancerous breast lesions. They can be seen both on mammograms and under the microscope. Because certain calcifications are found in areas containing cancer, their presence on a mammogram may lead to a biopsy of the area. Then, when the biopsy is done, the pathologist looks at the tissue removed to be sure that it contains calcifications. If the calcifications are there, the treating physician knows that the biopsy sampled the correct area (the abnormal area with calcifications that was seen on the mammogram).
Microcalcifications and calcifications only matter because they are sometimes found in areas containing cancer. When they are found alone (without worrisome changes in the breast ducts or lobules), they are not important.
Last Medical Review: October 14, 2014 Last Revised: October 14, 2014
Copyright 2011 Association of Directors of Anatomic and Surgical Pathology, adapted with permission by the American Cancer Society.