Survival Rates for Oral Cavity and Oropharyngeal Cancer

Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed. They can’t tell you how long you will live, but they may help give you a better understanding of how likely it is that your treatment will be successful.

Keep in mind that survival rates are estimates and are often based on previous outcomes of large numbers of people who had a specific cancer, but they can’t predict what will happen in any particular person’s case. These statistics can be confusing and may lead you to have more questions. Ask your doctor, who is familiar with your situation, how these numbers might apply to you.

What is a 5-year relative survival rate?

A relative survival rate compares people with the same type and stage of cancer to people in the overall population. For example, if the 5-year relative survival rate for a specific stage of cancer is 90%, it means that people who have that cancer are, on average, about 90% as likely as people who don’t have that cancer to live for at least 5 years after being diagnosed.

Where do these numbers come from?

The American Cancer Society relies on information from the Surveillance, Epidemiology, and End Results (SEER) database, maintained by the National Cancer Institute (NCI), to provide survival statistics for different types of cancer.

The SEER database tracks 5-year relative survival rates for oral cavity and oropharyngeal cancers in the United States, based on how far the cancer has spread. The SEER database, however, does not group cancers by AJCC TNM stages (stage 1, stage 2, stage 3, etc.). Instead, it groups cancers into localized, regional, and distant stages:

• Localized: There is no sign the cancer has spread outside the organ where it started (for example, the lip, tongue, or floor of mouth).
• Regional: The cancer has spread to nearby structures or lymph nodes.
• Distant: The cancer has spread to distant parts of the body such as the lungs.

5-year relative survival rates for oral cavity and oropharyngeal cancers

These numbers are based on people diagnosed with cancers of the oral cavity (mouth) or oropharynx (the part of the throat behind the mouth) between 2015 and 2021.

Lip

SEER Stage	5-Year Relative Survival Rate
Localized	95%
Regional	62%
Distant	46%
All SEER stages combined	90%

Tongue

SEER Stage	5-Year Relative Survival Rate
Localized	88%
Regional	70%
Distant	39%
All SEER stages combined	71%

Floor of the mouth

SEER Stage	5-Year Relative Survival Rate
Localized	72%
Regional	43%
Distant	22%
All SEER stages combined	52%

Oropharynx

SEER Stage	5-year Relative Survival Rate
Localized	62%*
Regional	67%*
Distant	27%
All SEER stages combined	57%

*The 5-year relative survival for these cancers at the regional stage is slightly better than for the localized stage. The reason for this is not clear, although it's important to know that these rates are based on small numbers of cases.

Understanding the numbers

• These numbers apply only to the stage of the cancer when it is first diagnosed. They do not apply later on if the cancer grows, spreads, or comes back after treatment.
• These numbers don’t take everything into account. Survival rates are grouped based on how far the cancer has spread, but your age and overall health, how well the cancer responds to treatment, and other factors will also affect your outlook. Currently, these survival rates are not based on the p16 (HPV) status of the cancer, which could also affect your outlook.
• People now being diagnosed with oral cavity or oropharyngeal cancer may have a better outlook than these numbers show. Treatments improve over time, and these numbers are based on people who were diagnosed and treated at least 5 years earlier.