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Tests for Soft Tissue Sarcomas
If you have signs or symptoms that suggest you might have a soft tissue sarcoma, the doctor will likely need to do tests to find out if you have cancer.
Imaging tests
Imaging tests are used to create pictures of the inside of the body. Imaging tests can be done to:
- Look at suspicious areas that might be cancer
- Help guide a needle into place during a biopsy
- See whether cancer has spread, and if so, how far
- Help find out if treatment is working
- Look for signs that the cancer has come back after treatment
A CT scan uses x-rays to make detailed images of your body. This test is often done if the doctor suspects a soft tissue sarcoma in the chest, abdomen (belly), or the retroperitoneum (the back of the abdomen). This test is also used to see if the sarcoma has spread to the lungs, liver, or other organs.
CT scans might be used to guide a biopsy needle into a tumor inside the body. This is called a CT-guided needle biopsy. You lie on the CT scanning table while a radiologist moves a biopsy needle toward the tumor.
MRI uses radio waves and strong magnets (not x-rays) to take pictures of the inside of the body. MRI scans are often part of the workup of any tumor that could be a sarcoma. They're often better than CT scans in evaluating sarcomas in the arms or legs.
MRIs can show your health care team many things about the tumor, like where it is, how big it is, and sometimes the type of tissue it comes from, like bone, fat, or muscle. MRIs are also very helpful in examining the brain and spinal cord.
Ultrasounds use sound waves and their echoes to look inside the body. For this test, a small, wand-like instrument called a transducer is moved around on the skin, which creates an image that can be seen on a computer screen. The test uses no radiation and does not cause any pain.
An ultrasound might be done before a biopsy to see if a lump is a cyst (a non-cancerous fluid-filled lump) or more likely a tumor. This test is often not needed if a CT or MRI scan is done.
PET scans aren't often used for soft tissue sarcomas, but can be helpful in some cases. For a PET scan, a slightly radioactive form of sugar, known as FDG, is injected into the blood and collects mainly in cancer cells. These areas of radioactivity can be seen on a PET scan using a special camera.
A PET scan is useful when your doctor thinks the cancer has spread but doesn't know where.
PET/CT scan: Some machines can do both a PET and CT scan at the same time. This lets the doctor compare areas of higher radioactivity on the PET scan with the more detailed picture of that area on the CT scan.
Biopsy
In many cases, the only way to know for sure if a person has a soft tissue sarcoma is to get a biopsy (a small sample) from the suspicious area and look at it in the lab. This procedure can be done in different ways. Doctors experienced with these tumors will choose one, based on the size and location of the tumor.
Most prefer to use a core needle biopsy, which uses a hollow needle to take out pieces of tissue from a suspicious area.
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- References
Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).
Helman LJ, Maki RG. Sarcomas of soft tissue. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE. Abeloff‘s Clinical Oncology. 6th ed. Philadelphia, PA. Elsevier: 2019.
National Cancer Institute. Adult Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version. February 21, 2025. Accessed at www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq on Dec 2, 2025.
National Comprehensive Cancer Network, Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, Version 1.2025 – May 2, 2025. Accessed at www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf on Nov 20, 2025.
Singer S, Maki R, O’Sullivan B. Soft tissue sarcoma In: DeVita VT, Heilman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 11th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2019.
Last Revised: February 9, 2026
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