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Researchers have found some risk factors for prostate cancer, although it’s not yet clear exactly how these factors might increase prostate cancer risk. On a basic level, prostate cancer is caused by changes in the DNA of a normal prostate cell.
DNA is the chemical in our cells that makes up our genes, which control how our cells function. We usually look like our parents because they are the source of our DNA. But our genes affect more than just how we look.
Some genes normally help control when our cells grow, divide to make new cells, or repair mistakes in DNA, or they cause cells to die when they’re supposed to. If these genes aren’t working properly, it can lead to cells growing out of control. For example:
Any of these types of DNA changes might lead to cells growing out of control and forming a tumor. To learn more, see Oncogenes, Tumor Suppressor Genes, and DNA Repair Genes.
DNA changes can either be inherited from a parent, or they can be acquired during a person’s lifetime.
Some gene mutations can be passed on in families and are found in all of a person’s cells. Such inherited gene changes are thought to be a major factor in up to 10% of prostate cancers. Cancer caused by inherited genes is called hereditary cancer.
Inherited mutations in several genes have been linked to hereditary prostate cancer, including:
Other inherited gene mutations may account for some hereditary prostate cancers, and research is being done to find these genes.
If you have prostate cancer, testing the cancer cells for these types of gene changes might be important, for a couple of reasons:
Some genes can change during a person’s lifetime. This type of mutation is not passed on to children, and it’s found only in cells that come from the original mutated cell. These are called acquired mutations. Most gene mutations linked to prostate cancer develop during a man’s life, rather than having been inherited.
Every time a cell prepares to divide into 2 cells, it needs to make a copy of its DNA for the new cell. This process isn’t perfect, and sometimes errors occur, leaving defective DNA in the new cell. It’s not clear how often these DNA changes might be random events, and how often they are influenced by other factors (such as diet, hormone levels, etc.).
In general, the more quickly prostate cells grow and divide, the more chances there are for mutations to occur. Therefore, anything that speeds up this process might make prostate cancer more likely.
For example, androgens (male hormones), such as testosterone, can promote prostate cell growth. Having higher levels of androgens might contribute to prostate cancer risk in some men, although studies so far have not found a consistent link.
Some research has found that men with high levels of another hormone, insulin-like growth factor-1 (IGF-1), might be more likely to get prostate cancer. However, other studies have not found such a link. Further research is needed to make sense of these findings.
As mentioned in Prostate Cancer Risk Factors, some studies have found that inflammation in the prostate might be linked to prostate cancer. One theory is that inflammation might lead to cell DNA damage, which could contribute to a normal cell becoming a cancer cell. More research is needed in this area.
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
Cheng HH, Nelson PS. Genetic risk factors for prostate cancer. UpToDate. 2023. Accessed at https://www.uptodate.com/contents/genetic-risk-factors-for-prostate-cancer on June 26, 2023.
National Cancer Institute. Physician Data Query (PDQ). Genetics of Prostate Cancer. 2023. Accessed at https://www.cancer.gov/types/prostate/hp/prostate-genetics-pdq on June 26, 2023.
National Cancer Institute. Physician Data Query (PDQ). Prostate Cancer Prevention. 2023. Accessed at https://www.cancer.gov/types/prostate/hp/prostate-prevention-pdq on June 26, 2023.
National Comprehensive Cancer Network (NCCN). Practice Guidelines in Oncology: Prostate Cancer. Version 1.2023. Accessed at www.nccn.org/professionals/physician_gls/pdf/prostate.pdf on June 26, 2023.
Zelefsky MJ, Morris MJ, Eastham JA. Chapter 70: Cancer of the Prostate. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 11th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2019.
Last Revised: November 22, 2023