The American Cancer Society (ACS) and Lisa Dean Moseley Foundation are collaborating to create a research consortium that will advance the translation of cancer stem cell discoveries to accelerate the impact on patients.
The consortium will offer grants to the most promising research proposals, including for a Consortium Leader who will serve as a visionary in the field of cancer stem cells to lead these funded individuals and teams to work as a collaborative community.
All interested individuals and teams should design their research proposals to advance the understanding of cancer stem cells and leverage that knowledge to develop and test innovative strategies that help prevent cancer stem cells’ contribution to treatment resistance, metastasis, disease recurrence, cancer mortality, or a combination of these issues.
Applications Open in proposalCENTRAL:
January 2022
Interactive Webinar to Learn More:
January 31, from 12 to 1 EST (Webinar will be recorded and available upon request.)
Microsoft Teams meeting
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Or call in (audio only) +1 917-727-7985
Conference ID: 409 320 103#
LOI Due Date (Only for Consortium Lead and Interdisciplinary Team Awards): March 15, 2022 at 11:59 pm ET
Invitation-to-Apply Date (Only for Consortium Lead and Interdisciplinary Team Awards):
April 1, 2022
Application Deadline (all mechanisms):
June 1, 2022
Award Notification: December 2022
Grant Activation: January 2023
+We anticipate that the work of these individuals and of the collaborative community, will improve the scientific community’s ability to detect and target cancer stem cells and influence the development of much-needed, personalized and durable cancer treatments.
Many cancer therapies work by killing rapidly dividing cells, which includes most cells within tumors. These treatments initially cause tumors to shrink or become undetectable, which gives patients hope.
But cancer stem cells, a small subset of cells within tumors, have an exquisite ability to change the way they look and function, allowing them to hide from the immune system, evade destruction by cancer drugs or irradiation, and also to metastasize.
Even though a relatively small number of cancer stem cells may remain after treatment, they can lead to the recurrence of the original tumor, life-threatening metastasis to distant vital organs, and development of treatment resistance.
Cancer stem cells could be the Achilles’ heel for effective frontline oncology treatments. New therapies that seek and destroy cancer stem cells offer a new hope for preventing cancer’s recurrence and devastating progression.
There are significant knowledge gaps about how cancer stem cells can be so persistent in a variety of cancer types. Our goal for this substantial investment to study cancer stem cells is to maximize the knowledge gained from this newly created community of multidisciplinary scientists so that outcomes for patients can improve more quickly.
All proposals should be hypothesis-driven with a focus on cancer stem cells and include an articulated vision for reducing the burdens of cancer. We welcome projects along the cancer research continuum, especially those integrating multi-disciplinary approaches with near-term clinical impact. Examples of possible research areas include:
This Cancer Stem Cell Consortium offers funding opportunities for independent faculty at all ranks and for postdoctoral fellows.
Applications must be submitted by a college, university, medical school, or other eligible not-for-profit research organization within the United States, its territories, or the Commonwealth of Puerto Rico.
Applicants should review the American Cancer Society’s Cancer Stem Cell Consortium Instructions and Cancer Stem Cell Consortium Policies
Overview: The Consortium Leader helps address research challenges and needs of consortium members (~15 PIs), encourage community collaborations, moderate virtual and onsite meetings/retreats, and advise ACS Extramural Discovery Science (EDS) staff about developing shared resources, communication materials, and retreat agendas.
Eligibility: You ARE eligible to submit a proposal if you have:
Note: Receipt of this award will not preclude future ACS funding opportunities if the PI meets all eligibility requirements for that funding mechanism.
Grant Term and Budget: The award is for a 6-year term with $660K for direct costs, which includes $30K a year for administrative support and $80K a year for salary or cancer stem cell-related project support.
Letter-of-Intent (LOI) Requirements and Due Date: By March 15, 2022 submit via proposalCENTRAL (1) Your curriculum vitae with a complete bibliography and (2) an LOI.
The LOI should be a maximum of 2 pages that describes:
Invitation to Apply Date: By April 1, 2022, invitation-to-apply decisions will be communicated to applicants via proposalCENTRAL. That correspondence will include a link to the grant application and instruction materials posted on proposalCENTRAL.
Interdisciplinary Team Award
Overview: The selected research team includes interdisciplinary members to promote transformational advances in cancer stem cell research. The team must consist of at least 3 members: Lead PI and at least 1 Team Principal and 1 Team Investigator.
Team Members:
Grant Term and Budget: The award is for a 5-year term with $1.2M total costs ($200K a year plus 20% allowable indirect costs)
Letter-of-Intent (LOI) Requirements and Due Date: By March 15, 2022 submit via proposalCENTRAL:
Invitation to Apply Date: By April 1, 2022, invitation-to-apply decisions will be communicated to applicants via proposalCENTRAL. That correspondence will include a link to the grant application and instruction materials posted on proposalCENTRAL.
Research Scholar Grant
Overview: Funds an independent research project related to cancer stem cells
Eligibility: You ARE eligible to submit a proposal if you are a:
Note: PI eligibility for this RFA is extended beyond the ACS standard career-launching RSG.
Grant Term and Budget: Awards are for up to 4 years with $165K a year direct costs, plus 20% allowable indirect costs
Clinician-Scientist Development Grant
Overview: Provides protected time for junior faculty to be mentored and participate in cancer stem cell-related research training to aid their development as independent clinician scientists
Eligibility: You ARE eligible to submit a proposal if you are a:
Grant Term and Budget: Award is for 3 to 5 years with $135K direct costs a year, plus 8% allowable indirect costs
Postdoctoral Fellowship
Overview: Funds training for a career in cancer research
Eligibility: You are eligible if you are:
Grant Term and Budget: Awards are for 2 to 3 years with progressive stipends, plus an annual $4K fellowship allowance and $1,500 travel allowance in the last year
Additional Questions: For questions about the Cancer Stem Cell Consortium funding opportunities or associated collaborative community, please contact Lynne Elmore at lynne.elmore@cancer.org or Kimberly Clarke at kimberly.clarke@cancer.org.
See Cancer Stem Cell Consortium Instructions PDF and Cancer Stem Cell Consortium Policies PDF
* An eligible independent investigator can apply for the Consortium Lead, Interdisciplinary Team Award Lead PI, Team Principal, Team Investigator, and/or Research Scholar Grant but can only accept 1 award as PI.
Goes to proposalCENTRAL