Surgery for Lymphoma in Children

Surgery usually doesn’t have a major role in treating lymphoma in children because it is unlikely to cure most lymphomas by itself. But it might be used in some situations.

When is surgery used for lymphoma in children?

Surgery might be used for some Burkitt lymphomas, certain rare pediatric lymphomas, and in other situations, such as a biopsy.  

Burkitt lymphoma

Surgery is sometimes used as the first treatment for early-stage Burkitt lymphoma that is only in one area, such as part of the intestine. The goal is to remove as much of the tumor as possible before chemotherapy (chemo).

If the lymphoma can be removed completely, a child might be able to get a less intensive chemo regimen.

Follicular lymphoma or nodal marginal zone lymphoma

For some rare pediatric lymphomas, including follicular lymphoma and nodal marginal zone lymphoma, surgery may cure the cancer.

Other uses

Surgery might be used in other situations, including:

  • Getting biopsy samples to help determine the exact type of lymphoma, if doctors can’t get enough tissue with a nonsurgical procedure such as a needle biopsy or bone marrow biopsy.
  • Inserting a central venous catheter (CVC) or venous access device (VAD). This is a small plastic tube placed into a large blood vessel near the heart. The end of the tube stays just under a child’s skin or sticks out in their chest area or upper arm. It is left in place during treatment to give intravenous (IV) drugs such as chemo and to take blood samples. This lowers the number of needle sticks during treatment.
  • Treating some emergency situations, such as lymphoma blocking a child’s intestines.

Possible risks and side effects of surgery

The possible complications of any surgery depend on its location, the extent of the operation, and a child’s health beforehand. Serious complications are rare but can include problems with anesthesia, bleeding, blood clots, wound infections, and pneumonia.

Most children will have some pain for a while after surgery, although medicines can usually help control the pain if needed.

More information about surgery

For more general information about surgery as a treatment for cancer, see Cancer Surgery.

To learn about some of the side effects listed here and how to manage them, see Managing Cancer-related Side Effects.

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Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

Cole PD, Parikh RR, Kelly KM. Chapter 18: Hodgkin Lymphoma. In: Blaney SM, Adamson PC, Helman LJ, eds. Pizzo and Poplack’s Pediatric Oncology. 8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2021.

Gross TG, Kamdar KY, Bollard CM. Chapter 19: Malignant Non-Hodgkin Lymphomas in Children. In: Blaney SM, Adamson PC, Helman LJ, eds. Pizzo and Poplack’s Pediatric Oncology. 8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2021.

National Cancer Institute. Childhood Non-Hodgkin Lymphoma Treatment (PDQ). 2025. Accessed at https://www.cancer.gov/types/lymphoma/hp/child-nhl-treatment-pdq on November 11, 2025.

Last Revised: February 27, 2026

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