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Surgery for Testicular Cancer

Surgery is the first treatment for nearly all testicular cancers.

Radical inguinal orchiectomy

Surgery to remove a testicle with cancer is called a radical inguinal orchiectomy. An incision (cut) is made just above the pubic area, and the testicle is removed from the scrotum through the opening. The surgeon then removes the entire tumor along with the testicle and spermatic cord. The spermatic cord contains part of the vas deferens (tube that allows sperm to move out of the testis), as well as blood and lymph vessels that could act as pathways for testicular cancer to spread to the rest of the body. To lessen the chance of this, these vessels are tied off early in the operation.

All testicular cancers are typically treated with this surgery, even those that have spread.

Cancer may develop in both testicles at the same time or at different times. This is rare, occurring in about 2% of people with testicular cancer. Then, both testicles usually need to be removed in a procedure called a bilateral orchiectomy. In some cases where testicular cancer is in both testicles, testicle-sparing surgery can be done on one side so that part of 1 testicle remains, but this is not commonly done.

If an orchiectomy is done, a sample of blood will be collected before surgery to test for levels of serum tumor markers because they are often helpful in planning treatment and follow-up care. For example, increasing or consistently high alpha-fetoprotein (AFP) or beta human chorionic gonadotropin (beta-hCG) after surgery is a sign that cancer has spread. In this situation, a patient usually needs chemotherapy, even if the metastases cannot be seen on imaging tests.

After having a radical inguinal orchiectomy, an option for people with clinical stage I testicular cancer (seminoma or non-seminoma) may be surveillance. The advantage of surveillance is that patients may avoid additional treatment that may not be needed. With surveillance, the patient is monitored closely, and active treatment begins only if the cancer recurs. This option involves regular doctor appointments for physical examinations, blood tests for tumor markers, computed tomography (CT) scans, and chest x-rays. This approach requires dedication by the doctor and patient to stick to the surveillance schedule so that any recurrence can be detected at an early stage. It is only considered as an option if AFP and beta-hCG levels are normal or return to normal after the testicle with cancer is removed.

The main advantage of surveillance is that it avoids any further treatment after orchiectomy for those who do not have the disease return. About 82% of patients with seminoma and 75% of patients with non-seminoma will not have the disease return after orchiectomy. For an individual patient, the risk of recurrence may be higher or lower based on risk factors determined by the pathologist’s examination of the tumor after the testicle has been removed.

Partial orchiectomy

Partial orchiectomy, also known as testis-sparing surgery (TSS), removes the testicular tumor while keeping healthy testicular tissue. The surgery is done through an inguinal approach to prevent cancer spread. Though not standard, partial orchiectomy helps select patients maintain hormone function and fertility while requiring strict follow-up care.

Partial orchiectomy can be considered for patients with cancer in both testicles, a single testicle with cancer, or a poorly functioning other testicle to maintain testosterone and fertility.

  • It can preserve testosterone production, thereby reducing the need for hormone replacement therapy.
  • It can maintain fertility.
  • It can maintain quality of life by avoiding low testosterone-related issues like low energy, mood changes, osteoporosis, and sexual dysfunction.

  • It is associated with a higher risk of the testicular cancer returning.
  • After surgery, close lifelong monitoring is necessary.
  • After surgery, radiation is usually recommended, which can affect sperm and testosterone.

Retroperitoneal lymph node dissection (RPLND)

Depending on the type and stage of your cancer, lymph nodes around the large blood vessels (the aorta and inferior vena cava) at the back of the abdomen (belly) may be removed at the same time as the orchiectomy or during a second operation. Not all people with testicular cancer need to have lymph nodes removed, so it’s important to discuss this with your doctor.

This is a complex and long operation. In most cases, a large incision (cut) is made down the middle of the abdomen to remove the lymph nodes. RPLND should be done by a surgeon who does this often. Experience is important.

In some cases, the surgeon can remove lymph nodes through very small skin incisions in the abdomen by using a laparoscope and other long, thin surgical tools. A laparoscope is a narrow, lighted tube with a small camera on the end that lets doctors see inside the abdomen. The surgeon’s hands are not inside the patient’s body during this type of surgery.

In laparoscopic surgery, after being put to sleep, you’re turned onto your side. Several small incisions are made on your abdomen. The laparoscope and surgical tools are put in through the incisions to remove the lymph nodes. The incisions are then closed.

Patients recover much more quickly from this operation than the standard open procedure and are walking soon after surgery. There’s usually less pain and patients are eating sooner.

Laparoscopic surgery seems to be a lot easier for the patient, but doctors aren’t sure if it’s as safe and effective as the standard “open” surgery in removing all the lymph nodes that may contain cancer. Because of this uncertainty, doctors are more likely to recommend chemotherapy after laparoscopic surgery if cancer is found in the lymph nodes.

This procedure is most often used for patients with early-stage non-seminomas to see if the lymph nodes contain cancer. As with the standard open procedure, this is a complex operation that should only be done if the surgeon is very experienced.

Possible risks and side effects of surgery

The short-term risks of any type of surgery include reactions to anesthesia, excess bleeding, blood clots, and infections. Most men will have at least some pain after the operation, which can be helped with pain medicines, if needed.

Losing one testicle usually has no effect on a man’s ability to get an erection and have sex. But if both testicles are removed, sperm cannot be made, and a man becomes infertile. Also, without testicles, a man cannot make enough testosterone, which can decrease sex drive and affect his ability to have erections. Other effects could include fatigue, hot flashes, and loss of muscle mass. These side effects can be avoided by taking testosterone supplements, either in a gel, a patch, or a shot. Pills are generally not reliable sources of testosterone.

Testicular prosthesis

Usually, men with testicular cancer are young and may be concerned about changes in how they look. They may be dating and worry about a partner’s reaction, or they may feel embarrassed by the missing testicle when in locker rooms.

To restore a more natural look, a man can have a testicular prosthesis surgically implanted in his scrotum. The prosthesis approved for use in the United States is filled with saline (salt water) and comes in different sizes to match the remaining testicle. When in place, it can look like a normal testicle. There can be a scar after the operation, but it’s often partly hidden by pubic hair. Some men might want a prosthesis, while others might not. You should discuss your wishes with your surgeon before surgery. It could also help to talk with someone who has a testicular prosthesis to hear what it has been like for them.

An RPLND, a surgery to remove retroperitoneal lymph nodes, is a major operation. Serious complications are not common, but they can happen. About 5-10% of patients have short-term problems after surgery, such as infection or bowel obstruction (blockage). The standard approach for an RPLND requires a large incision in the abdomen, which will leave a scar and can take some time to heal. Your ability to get up and move around after the operation will be limited for some time. This is less likely to be an issue if you have laparoscopic surgery, which uses smaller incisions.

Retrograde ejaculation

An RPLND usually does not cause impotence – a man can still have erections and sex. However, this surgery may cause problems with ejaculation. If certain nerves are damaged during the RPLND, when a man ejaculates, the semen may go backward into the bladder and not come out through the urethra to exit the body. This is called retrograde ejaculation, which can make it hard to father children.

To avoid this ejaculation dysfunction, surgeons have developed a type of retroperitoneal lymph node surgery called nerve-sparing surgery. It can be a good option for certain patients, when done by experienced doctors. Testicular cancer often affects men at an age when they might be trying to have children. These men may wish to discuss nerve-sparing surgery with their doctors, as well as sperm banking (freezing and storing sperm cells obtained before treatment). Men with testicular cancer often have lower-than-normal sperm counts, which can sometimes make it harder to collect a good sperm sample. See How Cancer and Cancer Treatment Affect Fertility in Men for more about this.

More information about surgery

For more general information about surgery as a treatment for cancer, see Cancer Surgery.

To learn about some of the side effects listed here and how to manage them, see Managing Cancer-related Side Effects.

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Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

Chovanec M, Cheng L. Advances in diagnosis and treatment of testicular cancer. BMJ. 2022 Nov 28;379:e070499. doi: 10.1136/bmj-2022-070499. PMID: 36442868.

National Comprehensive Cancer network. NCCN Clinical Guidelines in Oncology (NCCN Guidelines). Testicular Cancer. Version 1.2025 – Jan 17, 2025.  Accessed at https://www.nccn.org on Feb 18, 2025.

Last Revised: August 10, 2025

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