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Laryngeal and Hypopharyngeal Cancer
Laryngeal and hypopharyngeal cancers start in the head and neck area. Cancer that starts in the larynx (voice box) is called laryngeal cancer. Cancer that starts in the hypopharynx (the lower part of the throat right behind the voice box) is called hypopharyngeal cancer. These cancers start when cells in the larynx or hypopharynx grow out of control and crowd out normal cells.
Cancers that start in the head and neck area can have many different names depending on where it is. Ask your doctor to write down the exact kind of cancer you have because it can be confusing.
The information after the pictures below is about laryngeal and hypopharyngeal cancers.
Explore the 3D, interactive color model of the larynx and hypopharynx to learn more. Ask your doctor to use these pictures to show you where the cancer is.
The mouth and throat
Cancer cells can spread to other parts of the body. Cancer cells from the larynx or hypopharynx can sometimes travel to the lungs and grow there. When cancer cells do this, it’s called metastasis. The cancer cells in the new place look just like the ones from the larynx or hypopharynx where it started.
Cancer is always named for the place where it starts. So when laryngeal or hypopharyngeal cancer spreads to the lung (or any other place), it’s still called laryngeal or hypopharyngeal cancer. It’s not called lung cancer unless it starts from cells in the lung.
The most common type of cancer in the larynx and hypopharynx is called squamous cell carcinoma (cancer). These cancers start in the squamous cells that line the voice box and vocal cords (larynx) and the lower part of the throat behind the voice box (hypopharynx).
These cancers may not be found until they cause problems that make the person go to the doctor. Sometimes changes are seen during a routine visit to the doctor or dentist. You may be sent to see a doctor who focuses on diseases of the ear, nose, and throat (called an ENT doctor, an otolaryngologist, or a head and neck surgeon).
The doctor will ask you questions about your health, your smoking and alcohol drinking history, and will do exams and tests to find out what is causing your symptoms. If signs point to laryngeal or hypopharyngeal cancer, you might have more tests. Here are some of the tests you might need:
Complete head and neck exam: The doctor will check your head and neck area, looking and feeling for any abnormal areas. The lymph nodes in the neck will be felt. Because some parts of your mouth and throat are not easily seen, the doctor may use mirrors, lights, and/or special fiber-optic scopes (thin lighted tubes) to look at these areas.
Panendoscopy: This exam is done in an operating room after you are given drugs to make you sleep. The surgeon looks inside your nose, mouth, throat, esophagus (swallowing tube), and trachea (windpipe) through thin tubes called scopes and may take out pieces of tissue (biopsies) to be checked closely in the lab.
CT scan: This is also called a CAT scan. It’s a special kind of x-ray that takes detailed pictures that shows if the cancer has spread to the lymph nodes, lungs, or other organs. CT scans can also be used to help do a biopsy (see below).
MRI scan: MRI scans use radio waves and strong magnets instead of x-rays to take detailed pictures. MRIs can be used to learn more about the size of the cancer and if it has spread to nearby structures or other areas of the body.
Chest x-rays: X-rays may be done to see if the cancer has spread to the lungs.
PET scan: A PET scan uses a special kind of sugar that can be seen inside your body with a special camera. If there is cancer, this sugar shows up as “hot spots” where the cancer is found. This test can help show if the cancer might have spread.
Barium swallow: For this test, x-rays are taken while you swallow a liquid with barium in it. Barium coats the inside surface of the throat and helps make a good picture. This test might be done if you are having trouble swallowing because it helps to see how your throat looks as you swallow.
Dental exam: Your dentist will probably do a complete exam and maybe some x-rays of your teeth before any radiation is given because radiation can damage the saliva (spit) glands and cause dry mouth. The dentist might also remove bad teeth to lower the chances of cavities and infection.
Hearing test: The most common chemo drug used to treat laryngeal and hypopharyngeal cancer, cisplatin, can cause ringing in your ears or even hearing loss. You might have your hearing checked (with an audiogram) before starting treatment and your chemotherapy might be changed if your hearing is poor to start with.
Nutrition and speech tests: A nutritionist might check your nutrition status before, during, and after treatment to try and keep your body weight and protein levels as normal as possible. A speech therapist might test how well you swallow and speak. They might give you exercises to do to help strengthen the muscles so that you can eat and talk normally after finishing treatment.
Biopsy: For this test, the doctor takes out a small piece of tissue with surgery or a needle, where the cancer seems to be. The tissue is checked for cancer cells. This is the best way to know for sure if you have cancer.
Gene and protein tests: The cancer cells in the biopsy tissue might be tested for genes or proteins such as PD-L1. Knowing which genes or proteins your cancer has can help the doctor decide if treatments like immunotherapy might help.
Blood tests: Blood tests are not used to find cancer of the larynx or hypopharynx, but they can tell the doctor more about your overall health, like your kidney or liver function.
If you have laryngeal or hypopharyngeal cancer, the doctor will want to find out if and how far it has spread. This is called staging. Knowing the stage will help your doctor decide what type of treatment is best for you.
The stage describes the growth or spread of the cancer in the place it started. It also tells if the cancer has spread to other nearby organs or to organs farther away.
Your cancer can be stage 0, 1, 2, 3, or 4. The lower the number, the less the cancer has spread. A higher number, like stage 4, means a more serious cancer that has spread from where it started. Be sure to ask the doctor about the cancer's stage and what it means for you.
Smoking during cancer treatment is linked to more side effects, worse outcomes, and reduced benefit of treatment. It is best to stop smoking completely before starting treatment. Smoking also increases the risk of the cancer coming back after treatment as well as the risk of getting a new cancer. Quitting smoking for good is the best way to improve your chance of survival.
There are many ways to treat cancer of the larynx and hypopharynx:
You might get more than one type of treatment. Each treatment has some side effects that can usually be managed or even prevented. The plan that’s best for you will depend on:
Some of these cancers are in places that are hard to operate on. Still, surgery may be used to take out the cancer and an edge of healthy tissue around it. In some cases, all or part of the throat or voice box may need to be removed. Surgery may also be used to take out lymph nodes in the neck that might have cancer.
Surgery can also be used to help you do things that the cancer may have changed. For instance, if you can’t swallow because of the tumor, surgery may be done to put in a feeding tube. Some surgeries can even help rebuild part of the throat.
Any type of surgery can have risks and side effects. Ask the doctor what you can expect. If you have problems, let your doctors know. Doctors who treat people with laryngeal and hypopharyngeal cancers should be able to help you with any problems that come up.
Radiation uses high-energy rays (like x-rays) to kill cancer cells. It can be given alone or along with chemotherapy. Radiation can also be used to help with symptoms such as pain, bleeding, trouble swallowing, or other problems that happen if the cancer has grown very large or has spread to other areas.
There are 2 main ways radiation can be given.
If your doctor suggests radiation treatment, talk about what side effects might happen. Side effects depend on the type of radiation that’s used and the part of your body that’s treated. The most common side effects are:
Most side effects get better after treatment ends and many can be managed or even prevented. Some might last longer. Ask your cancer care team what you can expect.
Chemo, the short word for chemotherapy, is the use of drugs to fight cancer. The drugs may be given into a vein or taken as pills. These drugs go into the blood and spread through most of the body. Chemo is given in cycles or rounds. Each round of treatment is followed by a break. This gives the body time to recover. Most of the time, 2 or more chemo drugs are given. Treatment often lasts for many months.
For laryngeal and hypopharyngeal cancer, chemo is often given along with radiation. This is called chemoradiation.
Chemo can make you feel very tired, sick to your stomach, and your hair might fall out. But most of these problems go away after treatment ends. Other side effects like hearing problems or nerve damage can last a long time.
There are ways to treat most chemo side effects. If you have side effects, tell your cancer care team so they can help.
Targeted therapy drugs may be used for laryngeal or hypopharyngeal cancer. These drugs affect mainly cancer cells and not normal cells in the body. They may work even if other treatments don’t. These drugs have different side effects from chemo.
Side effects of targeted drug therapy depend on which drug is used. These drugs might cause a headache or diarrhea. They can also cause nail changes or a skin rash of the face or upper chest. These side effects usually go away after treatment ends.
There are ways to treat most of the side effects caused by targeted therapy. If you have side effects, talk to your cancer care team so they can help.
Immunotherapy is treatment that either boosts your own immune system or uses man-made versions of parts of the immune system that attack the cancer cells. Immunotherapy drugs may be given into a vein.
Immunotherapy can cause many different side effects depending on which drug is used. These drugs might make you feel tired, sick to your stomach, or cause a rash. Most of these problems go away after treatment ends.
More serious side effects might happen if the immune system starts attacking normal parts of the body, which can cause serious problems in many organs. You may need to stop the immunotherapy drug and take steroids to treat this side effect.
There are ways to treat most of the side effects caused by immunotherapy. If you have side effects, talk to your cancer care team so they can help.
Clinical trials are research studies that test new drugs or other treatments in people. They compare standard treatments with others that could be better.
Clinical trials are one way to get the newest cancer treatment. They are the best way for doctors to find better ways to treat cancer. If your doctor can find one that’s studying the kind of cancer you have, it’s up to you whether to take part. And if you do sign up for a clinical trial, you can always stop at any time.
If you would like to be in a clinical trial, start by asking your doctor if your clinic or hospital conducts clinical trials. See Clinical Trials to learn more.
When you have cancer you might hear about other ways to treat the cancer or treat your symptoms. These might not always be standard medical treatments. These treatments may be vitamins, herbs, special diets, and other things. You may be curious about these treatments.
Some of these are known to help, but many have not been tested. Some have been shown not to help. A few have even been found to be harmful. Talk to your doctor first if you’re thinking about using anything, whether it’s a vitamin, a diet, or anything else.
You’ll be glad when treatment is over. For years after treatment ends, you will see your cancer doctor. Be sure to go to all of these follow-up visits. You will have exams, blood tests, and maybe other tests to see if the cancer has come back.
Follow-up doctor visits after treatment may be needed as often as every few months for the first year, every 3 to 6 months during the 2nd year, and a little less often after that. During these visits, your doctor will ask about any symptoms you’re having, if you are using any products like cigarettes or chewing tobacco, and will do a physical exam. Laryngoscope exams, blood tests, dental exams, or imaging tests (like MRI or CT scans) may be done to look for signs of cancer or treatment side effects. Your doctor will tell you which tests should be done and how often, based on the stage of your cancer and the type of treatment you had.
Having cancer and dealing with treatment can be hard, but it can also be a time to look at your life in new ways. You might think about ways to improve your health. Call us at 1-800- 227-2345 or talk to your doctor to find out what you can do to feel better or to get help to quit smoking.
You can’t change the fact that you have cancer. What you can change is how you live the rest of your life – making healthy choices and feeling as well as you can.
Anyone with cancer, their caregivers, families, and friends, can benefit from help and support. The American Cancer Society offers the Cancer Survivors Network (CSN), a safe place to connect with others who share similar interests and experiences. We also partner with CaringBridge, a free online tool that helps people dealing with illnesses like cancer stay in touch with their friends, family members, and support network by creating their own personal page where they share their journey and health updates.
The American Cancer Society medical and editorial content team
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
Biopsy (BY-op-see): taking out a small piece of tissue to see if there are cancer cells in it
Epiglottis (EP-uh-GLOT-is): A thin, valve-like, flap at the base of the tongue that covers the vocal cord area when you swallow. This keeps food and drink from getting into the windpipe.
Esophagus (eh-SOF-uh-gus): the tube that carries food from the mouth to the stomach
Glottis (GLOT-is): the part of the larynx that contains the vocal cords
Hypopharynx (hi-po-FAIR-ingks): the lower part of the throat, from the voice box down to the esophagus
Larynx (lair-ingks): the voice box, which sits below the base of the tongue and at the top of the windpipe. It contains the vocal cords, which make sound.
Metastasis (muh-TAS-tuh-sis): cancer cells that have spread from where they started to other places in the body
Nasal cavity: the inside of the nose above the roof of the mouth
Nasopharynx (NAY-zoh-FAIR-ingks): the part of the throat that’s behind the nose
Oropharynx (OR-oh-FAIR-ingks): the part of the throat that’s behind the mouth
Subglottis (sub-GLOT-is): the lower part of the larynx, from just under the voice box to the top of the windpipe
Supraglottis (sub-GLOT-is): the upper part of the larynx, above the voice box
Trachea (TRAY-key-uh): the windpipe, the big tube that carries air in and out of the lungs
Voice box: the larynx, which sits below the base of the tongue and at the top of the windpipe. It contains the vocal cords which make sound.
We have a lot more information for you. You can find it online at www.cancer.org. Or, you can call our toll-free number at 1-800-227-2345 to talk to one of our cancer information specialists.
Last Revised: January 21, 2021
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