Anti-viral Drugs for Castleman Disease

Multicentric Castleman disease (CD) is sometimes associated with the virus HHV-8. Doctors have had success in treating some patients with multicentric CD with drugs that kill this virus, such as ganciclovir, valganciclovir, and foscarnet.

Many patients with HIV infection are treated with anti-retroviral therapy to keep the HIV in check. But the effect of therapy for HIV on CD is not clear.

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Lurain K, Yarchoan R, Uldrick TS. Treatment of Kaposi sarcoma herpes virus-associated multicentric Castleman disease. Cancer Sci. 2017;9 [Epub ahead of print].

National Cancer Institute. Physician Data Query (PDQ). AIDS-related lymphoma treatment. 10/02/2015. Accessed at: https://www.cancer.gov/types/adrenocortical/hp/adrenocortical-treatment-pdq  on January 11, 2018.

National Cancer Institute. Castleman disease. Accessed at https://seer.cancer.gov/seertools/hemelymph/532b3e3fe4b0626b1926ec92/ on January 10, 2018.

National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: B-cell lymphomas. v.7.2017. Accessed at https://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf  on January 11, 2018 . 

National Organization for Rare Disorders. Castleman disease. Accessed at https://rarediseases.org/rare-diseases/castlemans-disease/ on January 5, 2018.

van Rhee F, Greenway A, Stone K. Treatment of idiopathic Castleman disease. Hematol Oncol Clin North Am. 2018;32(1):89-106.

Last Medical Review: January 12, 2017 Last Revised: February 5, 2018

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Treating Castleman Disease