Long-term side effects of radiation therapy

During and right after radiation therapy, it can be hard to think ahead to what might happen many years in the future. But depending on the type of treatment and the location of the cancer, there may be long-term side effects from your radiation treatment. (Some of these are described in more detail in Managing side effects of treatment to certain parts of the body.)

Talk to your cancer care team about possible long-term problems from the treatment you’re getting. Even though they’re less common than short-term ones, these problems should still be taken into account when making decisions about radiation therapy.

Damage to your body

Radiation can damage normal cells, and sometimes this damage can have long-term effects. For instance, radiation to the chest area may damage the lungs or heart. In some people this might affect a person’s ability to do things. Radiation to the abdomen (belly) or pelvis can lead to bladder, bowel, fertility, or sexual problems in some people. Radiation in certain areas can also lead to fluid build-up and swelling in parts of the body, a problem called lymphedema.

See To learn more to find out where you can get more information on many of these long-term side effects.

Risk of another cancer

A long-term problem linked to radiation treatment is the possible increased risk of getting a second cancer many years later. This is caused by the radiation damage to healthy tissues. The risk of this happening is small but real.

The link between radiation and cancer was noted many years ago in studies of atomic bomb survivors, workers exposed to radiation on their jobs, and patients treated with radiation therapy. For instance, young women who had radiation to the chest for the treatment of Hodgkin disease were later found to be at increased risk for breast cancer and some other cancers. (This treatment is seldom used for Hodgkin disease today.) Some cases of leukemia are also linked to past radiation exposure. The risk of leukemia increases within a few years of exposure, peaks about 5 to 9 years after the radiation, and then slowly declines. Other types of cancer after radiation exposure often take much longer to develop. Most do not happen until at least 10 years after exposure, and some are diagnosed 15 or more years later.

Talk to your cancer care team about the possible long-term effects before you start radiation. This can help you make an informed treatment decision and help you know what symptoms you may need to watch for after treatment.

The American Cancer Society medical and editorial content team
Our team is made up of doctors and master’s-prepared nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Last Medical Review: June 30, 2015 Last Revised: June 30, 2015

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