Blood Transfusions for People with Cancer
A transfusion is putting blood or some part of it into a person’s vein through an intravenous (IV) line.
Transfusions of blood and blood products may be given to a person who is bleeding or who can’t make enough blood cells. Blood transfusions save millions of lives in the United States every year.
People usually donate whole blood – blood taken right out of a vein through a needle. This whole blood may be called a unit or pint of blood, and equals about 450 milliliters or 16.7 ounces. But whole blood is rarely given as a transfusion. Blood has many parts (called components), and each one does a different job. Whole blood is usually separated into red blood cells, platelets, and plasma. Plasma can be further separated into clotting factors and certain proteins. This lets doctors give patients only what they need. It also helps to get the most out of the donated blood.
Why people with cancer might need blood transfusions
People with cancer might need blood transfusions because of the cancer itself. For instance:
- Some cancers (especially digestive system cancers) cause internal bleeding, which can lead to anemia from too few red blood cells; see “Red blood cell transfusions” in the next section.
- Blood cells are made in the bone marrow, the spongy center of certain bones. Cancers that start in the bone marrow (like leukemias) or cancers that spread there from other places may crowd out normal blood-making cells, leading to low blood counts.
- People who have had cancer for some time may develop something called anemia of chronic disease. This anemia is caused by certain long-term medical conditions that affect the production and lifespan of red blood cells.
- Cancer can also lower blood counts by affecting organs such as the kidneys and spleen, which help keep enough cells in the blood.
Cancer treatments may also lead to the need for blood transfusions:
- Surgery to treat cancer may lead to blood loss and a need for red blood cell or platelet transfusions. (See “Red blood cell transfusions” and “Platelet transfusions” in the next section.)
- Most chemotherapy drugs affect cells in the bone marrow. This commonly leads to low blood cell counts, and can sometimes put a person at risk for life-threatening infections or bleeding.
- When radiation is used to treat a large area of the bones, it can affect the bone marrow and lead to low blood cell counts.
- Bone marrow transplant (BMT) or peripheral blood stem cell transplant (PBSCT) patients get large doses of chemotherapy and/or radiation therapy. This destroys the blood-making cells in the bone marrow. These patients often have very low blood cell counts after the procedure and need transfusions.
Types of transfusions
Red blood cell transfusions
Red blood cell basics
Red blood cells (RBCs) give blood its color. Their job is to carry oxygen from the lungs through the bloodstream to every part of the body. A substance in red blood cells called hemoglobin does this. Then, the red cells bring carbon dioxide (CO2) back to the lungs, where it’s removed from the body when we exhale.
Red blood cells (and all other blood cells) are normally made in the bone marrow, the soft inner part of certain bones. The production of RBCs is controlled by the kidneys. When the kidneys sense that there aren’t enough RBCs in the blood, they release a hormone called erythropoietin that causes the bone marrow to make more.
When red blood cell transfusions are used
Anemia: People who have low numbers of red blood cells (RBCs) are said to have anemia or be anemic. People who have anemia may need RBC transfusions because they don’t have enough RBCs to carry oxygen to all of the cells in the body. (Low iron or vitamin B12 levels are less common causes of anemia in cancer patients.)
A normal hemoglobin level is about 12 to 18 g/dL. A red blood cell transfusion may be suggested if it drops below 8 g/dL. Whether you need a transfusion for anemia depends on many factors, such as how long it took for the anemia to develop and how well your body is able to cope with it. Anemia due to a sudden loss of blood will probably need to be corrected right away. Anemia that develops slowly is less likely to cause problems, because the body has time to adjust to it to some extent. If your hemoglobin level is lower than normal but you’re not dizzy, pale, or short of breath, you may not need a transfusion.
Patients who have certain heart or lung diseases may be more affected by anemia and may need transfusions even if their hemoglobin level is not very low. Other conditions that increase the need for oxygen may also require transfusions.
There are drugs that can treat anemia instead of a transfusion in some patients, but they carry different risks, work slowly, and cost a lot. For more information about anemia and how it’s treated, see Anemia in People With Cancer.
Surgery: Transfusions may be given during or after surgery to make up for blood loss. In some cases, blood lost during surgery can be collected and given back to the patient. See “Intra-operative or post-operative blood salvage” in Alternatives to Blood Transfusion for more on this.
Plasma is the clear, pale-yellow liquid part of blood. It contains proteins (called clotting factors) that help make blood clot. This is important when the body is injured because clots are needed to help seal blood vessels and stop bleeding. Plasma also contains other proteins, such as antibodies, which help fight infection.
Once plasma is separated from the red blood cells, it can be frozen and kept for up to a year. Once thawed, it’s called fresh frozen plasma.
Plasma can be donated in a process called apheresis, or sometimes called plasmapheresis. The donor is hooked up to a machine that removes blood, separates the plasma, and puts it into a special container. The machine returns the red cells and other parts of the blood to the donor’s bloodstream.
When plasma transfusions are used
Plasma is commonly given to patients who are bleeding because their blood is not clotting the way it should. Cancer patients might also be given fresh frozen plasma if they have a problem called DIC (disseminated intravascular coagulation). In this rare condition, all of the clotting factors in the body are used up or broken down. Signs and symptoms (such as excessive bleeding and bruising) and blood tests help the doctor identify DIC.
Platelets are fragments of cells in blood and are another important part of the clotting process. They work with the clotting factors in plasma to help stop bleeding.
Platelets are usually found in the plasma, and like red blood cells, they can be separated from it. A unit of whole blood has only a small volume of platelets. It takes platelets from several units of whole blood to help keep a person from bleeding. A unit of platelets is defined as the amount that can be separated from one unit of whole blood.
Unlike red blood cells, platelets do not have a blood type (see “Blood types” in Getting a Blood Transfusion), so patients can usually get platelets from any qualified donor. For platelet transfusions, 6 to 10 units from different donors (called random donor platelets) are combined and given to adult patients at one time (they are called pooled platelets).
Platelets can also be collected by apheresis. This is sometimes called plateletpheresis. In this procedure, the donor is hooked up to a machine that removes blood, and keeps just the platelets. The rest of the blood cells and plasma are returned to the donor. Apheresis can collect enough platelets so that they don’t have to be combined with platelets from other donors. Platelets collected in this way are called single donor platelets. (You can find more information about this in Donating Blood.)
When platelet transfusions are used
Cancer patients may need platelet transfusions if their bone marrow is not making enough. This happens when platelet-producing bone marrow cells are damaged by chemo or radiation therapy or when they are crowded out of the bone marrow by cancer cells.
A normal platelet count is about 150,000 to 400,000 platelets per microliter (mcL) of blood, depending on the lab. When platelet counts drop below a certain level (often 20,000/mcL), a patient is at risk for dangerous bleeding. Doctors consider giving a platelet transfusion when the platelet count drops to this level or even at higher levels if a patient needs surgery or is bleeding. If there are no signs of bleeding, a platelet transfusion may not be needed even if the platelet count is low.
Different medicines can be used to help with low platelets depending on the cause of the low platelets.
Cryoprecipitate, or "cryo," is the name given to the small fraction of plasma that separates out (precipitates) when plasma is frozen and then thawed in the refrigerator. It has several of the clotting factors found in plasma, but they are concentrated in a smaller amount of liquid. A unit of whole blood has only a small amount of cryoprecipitate, so about 8 to 10 units (from different donors) are pooled together for one transfusion.
When cryoprecipitate transfusions are used
Cryoprecipitate may be given to replace several blood clotting factors such as:
- Factor VIII (missing in patients with hemophilia A)
- Von Willebrand factor (needed to help platelets work)
- Fibrinogen (a protein needed to form a clot)
Unless they’re bleeding, people with cancer rarely need cryoprecipitate.
White blood cell (granulocyte) transfusions
White blood cell basics
Chemotherapy can damage cells in the bone marrow, and patients getting chemo often have low white blood cell (WBC) counts. (The normal range for WBCs is 4,000 to 10,000 per mcL of blood.)
White blood cells, especially the type called neutrophils (NEW-trow-fills), are very important in fighting infections. When patients have low WBC counts, doctors carefully watch the number of neutrophils or the absolute neutrophil count (ANC). Neutropenia is when a person’s ANC goes below 1,000/mcL. People with neutropenia are at risk for serious infections, even more so if the count stays low for more than a week.
When white blood cell transfusions are used
White blood cell transfusions are given rarely. Research does not show that giving white blood cell transfusions lowers the risk of death or infection in people with low white blood cell counts or white blood cells that are impaired.
Instead of transfusing WBCs, doctors now commonly use drugs called colony-stimulating factors or growth factors to help the body make its own. These drugs stimulate the body to make neutrophils and other types of granulocytes.
AABB, American Red Cross, America’s Blood Centers, and the Armed Services Blood Program. Circular of Information for the Use of Human Blood and Blood Components. November 2013. Accessed at www.aabb.org/tm/coi/Documents/coi1113.pdf on June 20, 2016.
Babic A, Kaufman RM. Principles of platelet transfusion therapy. In: Hoffman R, Benz EJ, Shattil SJ, Furie B, et al, eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone; 2009:2219-2223.
Cata JP. Perioperative anemia and blood transfusions in patients with cancer: when the problem, the solution, and their combination are each associated with poor outcomes. Anesthesiology. 2015 Jan;122(1):3-4.
Cochrane Database of Systematic Reviews. Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction. Accessed http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005339.pub2/full on May 19, 2016.
Cushing MM, Ness PM. Principles of red blood cell transfusion. In: Hoffman R, Benz EJ, Shattil SJ, Furie B, et al, eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone; 2009:2209-2218.
de Almeida JP, Vincent JL, Galas FR, de Almeida EP, et al. Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial. Anesthesiology. 2015 Jan;122(1):29-38.
Domen RE. Blood Product Transfusions in the Hematologic Malignancies. In Sekeres MA, Kalaycio ME, Bolwell BJ, eds. Clinical Malignant Hematology. New York: McGraw-Hill; 2007:1127-1138.
Ghinea R, Greenberg R, White I, Sacham-Shmueli E, Mahagna H, Avital S. Perioperative blood transfusion in cancer patients undergoing laparoscopic colorectal resection: risk factors and impact on survival. Tech Coloproctol. 2013 Oct;17(5):549-554.
Glaspy J. Disorders of blood cell production in clinical oncology. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. Abeloff’s Clinical Oncology. 4th ed. Philadelphia, Pa: Churchill Livingstone; 2008:677-692.
Vassallo R, Benjamin RJ, Dodd R, Eder A, McLaughlin LGS, Stramer S, et al. for the American Red Cross. A Compendium of Transfusion Practice Guidelines. Second Edition 2013. Accessed at www.redcrossblood.org/sites/arc/files/59802_compendium_brochure_v_6_10_9_13.pdf on June 20, 2016.
Watkins T, Surowiecka MK, McCullough J. Transfusion indications for patients with cancer. Cancer Control. 2015 Jan;22(1):38-46.
Last Medical Review: June 20, 2016 Last Revised: June 20, 2016