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If breast cancer spreads, it typically goes first to nearby lymph nodes under the arm. It can also sometimes spread to lymph nodes near the collarbone or near the breastbone (the front center of the chest). Knowing if the cancer has spread to your lymph nodes helps doctors find the best way to treat your cancer.
If you have been diagnosed with breast cancer, it’s important to find out how far the cancer has spread. To help find out if the cancer has spread outside the breast, one or more of the lymph nodes under the arm (axillary lymph nodes) are removed and checked in the lab. This is an important part of staging. If the lymph nodes have cancer cells, there is a higher chance that cancer cells have also spread to other parts of the body. More imaging tests might be done if this is the case.
Lymph node removal can be done in different ways, depending on whether any lymph nodes are enlarged, how big the breast tumor is, and other factors.
If any of the lymph nodes under the arm or around the collarbone are swollen, they may be checked for cancer with a needle biopsy, either a fine needle aspiration (FNA) or a core needle biopsy. Less often, the enlarged node is removed with surgery. If cancer is found in the lymph node, more nodes will need to be removed (see below).
Even if the nearby lymph nodes are not enlarged, they will still need to be checked for cancer. This can be done in two ways:
Lymph node surgery is often done as part of the main surgery to remove the breast cancer, but sometimes it might be done as a separate operation.
In a sentinel lymph node biopsy (SLNB), the surgeon finds and removes the first lymph node(s) to which a cancer is likely to spread (called the sentinel nodes). To do this, a substance is injected into the tumor, the area around it, or the area around the nipple. This can be done with either:
Lymph vessels will carry these substances along the same path that the cancer would likely take. The first lymph node(s) the substance travels to will be the sentinel node(s).
After the substance has been injected, the sentinel node(s) can be found by:
Sometimes, both methods are used.
The surgeon cuts the skin over the lymph node area and removes the affected node(s).
The few removed lymph nodes are then checked closely in the lab for cancer cells by a pathologist. Sometimes, this is done during the surgery. Because there is a chance that other lymph nodes in the same area will also have cancer if cancer is found in the sentinel lymph node(s), the surgeon may go ahead with an axillary dissection (ALND) to remove more lymph nodes while you are still on the operating table. If no cancer cells are seen in the node(s) at the time of the surgery, or if they are not checked by a pathologist at the time of the surgery, they will be examined more closely over the next several days.
If cancer is found in the sentinel node(s) later, the surgeon may recommend an ALND at a later time to check more nodes for cancer. Studies have shown, however, that in some cases it may be safe to leave the rest of the lymph nodes behind. This is based on certain factors, such as the size of the breast tumor, what type of surgery is used to remove the tumor, and what treatment is planned after surgery, among other things.
Based on the studies that have looked at this, skipping the ALND may be an option for:
If there is no cancer in the sentinel node(s), it's very unlikely that the cancer has spread to other lymph nodes, so no further lymph node surgery will be needed.
SLNB is often considered for women with early-stage breast cancer and is typically not used for women with inflammatory breast cancer. It might be used for women with locally advanced breast cancer in certain instances, such as after neoadjuvant treatment.
Although SLNB has become a common procedure, it requires a great deal of skill. It should be done only by a surgeon who has experience with this technique. If you are offered this type of biopsy, ask your surgeon if they do them regularly.
In this procedure, anywhere from about 10 to 40 (though usually less than 20) lymph nodes are removed from the area under the arm (axilla) and checked for cancer spread. ALND is usually done at the same time as a mastectomy or breast-conserving surgery (BCS), but it can be done in a second operation. ALND may be needed:
A possible long-term effect of lymph node surgery is swelling in the arm or chest called lymphedema. Because any excess fluid in the arms normally travels back into the bloodstream through the lymph system, removing the lymph nodes sometimes blocks drainage from the arm, causing this fluid to build up.
Lymphedema is less common after a sentinel lymph node biopsy (SLNB) than an axillary lymph node dissection (ALND). The risk is thought to be in the range of 5% to 17% in women who have a SLNB and around 20% to 30% in women who have an ALND. It may be more common if radiation is given after surgery or in women who are obese. Sometimes the swelling lasts for only a few weeks and then goes away. But in some women, it lasts a long time. If your arm is swollen, tight, or painful after lymph node surgery, be sure to tell someone on your cancer care team right away.
You might also have limited movement in your arm and shoulder after surgery. This is more common after ALND than SLNB. Your doctor may advise exercises to help keep you from having long-lasting problems (a frozen shoulder).
Some women notice a rope-like structure that begins under the arm and can extend down toward the elbow. This is sometimes called axillary web syndrome or lymphatic cording. It is more common after ALND than SLNB. Symptoms may not appear for weeks or even months after surgery. It can cause pain and limit movement of the arm and shoulder. This often goes away without treatment, although some women may find physical therapy helpful.
Numbness of the skin on the upper, inner arm is a common side effect because the nerve that controls sensation (feeling) here travels through the lymph node area.
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
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Last Revised: January 3, 2023
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