Managing Cancer Care

When Cancer Isn’t Your Only Health Problem

Many people diagnosed with cancer also have other health problems like diabetes, high blood pressure, or heart disease. Learn what to expect if you have other health problems besides cancer and how they can be managed alongside your cancer care.

Other health problems people may have in addition to cancer

Some people with cancer are also affected with other health problems like:

  • High blood pressure and heart disease
  • Lung diseases like chronic obstructive pulmonary disease (COPD) and asthma
  • Diabetes (high blood sugar)
  • Kidney problems
  • Mental health conditions, like anxiety and depression
  • Mobility or balance problems
  • Memory or thinking challenges (cognitive changes)
  • Thyroid issues
  • Autoimmune diseases
  • Mouth or teeth problems

Many of the causes of these health problems can also cause cancer. These include lifestyle factors such as unhealthy diet, not being active, excess body weight, and using tobacco or alcohol. Similar to cancer, many of these problems are more likely to occur with increased age.

Some health problems have also been found to be risk factors for certain cancers. For example, type 2 diabetes is a risk factor for colorectal cancer.

How other health problems affect cancer treatment

It’s important to know how your other health problems affect cancer treatment. Some of the risks can include:

  • Unwanted reactions between your cancer treatment and other medicines, called drug interactions
  • Being unable to use some treatments or having to adjust how they’re given
  • Cancer or its treatment may make your other health problems worse. This could make it harder to finish cancer treatment as planned.
  • Slower recovery from cancer treatment
  • Symptoms may overlap, making it hard to tell what is causing the issue or making it worse
  • Increased risk of second cancers or death

Talk with your cancer care team about your other health problems and the medicines you take. They may help lower risks by changing the type or dose of your medicines.

How other health problems are managed during cancer treatment

Learn more about common health problems and how to manage them during cancer treatment.

Cancer treatments, like some types of chemotherapy (chemo) and targeted therapy, can affect the heart or blood pressure. This can be a concern for older adults, who already have a higher risk of heart and blood pressure problems.

Ask your cancer care team if your cancer treatment or any of your new medicines might affect your heart or blood pressure. Your care team may adjust them to protect your heart during cancer treatment. They may also test your heart function and blood pressure often during treatment.

Some types of chemo, immunotherapy, or radiation to the chest may increase your risk of inflammation of the lungs, cough, or shortness of breath. Tell your cancer care team if you have a chronic lung condition before starting cancer treatment. These include asthma, emphysema, and COPD.

If you have diabetes, you need to monitor your blood sugar (blood glucose) levels closely during cancer treatment. Some chemo treatments and medicines used for side effects, such as steroids, can raise your blood sugar levels. Levels might also go up because you are less physically active or under stress. Side effects like nausea and vomiting or changes in how you eat may also affect your blood sugar.

If you have diabetes, work with your cancer care team to make a plan to manage your blood sugar levels during treatment. This may mean checking your blood sugar more often or adjusting the dose of your diabetes medicine.

Kidney problems can affect people of any age, but they are more common in older adults. Some medicines, including certain chemo treatments, can harm the kidneys or worsen existing problems.

If you have kidney issues, your cancer care team will likely check your kidney function with regular blood tests. How well your kidneys work might determine the type of chemo you can have or how often it will be given.

Feeling sad or worried is normal. Most people experience brief times of anxiety or low mood. But when these feelings last and interfere with daily life, they are considered chronic conditions. Anxiety and depression are common in people with cancer. Some develop these problems after a cancer diagnosis, while others have them beforehand. These problems can occur at any age.

Anxiety or depression can make it harder to:

  • Make treatment decisions
  • Take medicines or attend tests on time
  • Ask for or accept support from loved ones

Anxiety and depression can be treated with therapy, medicine, or both. Support is also available through cancer support groups or counselors, social workers, and family or friends.

Always inform your team if you have a history of anxiety or depression. If you are already being treated for these problems, some medicines for anxiety or depression may interact with your treatments. Your team can help adjust your treatment if needed. Check with them before stopping or starting any medicines.

Existing pain, like arthritis or peripheral neuropathy or from a past injury, can make many cancer treatments harder. It may affect daily activities, exercise, or getting to appointments, and can increase the risk of some side effects.

Staying physically active is important for your overall health and quality of life, especially during cancer treatment. Tell your cancer care team about any pain or problems moving around that you have. They may suggest seeing a specialist, such as a physical or occupational therapist, or a cancer rehab expert to help you stay active safely.

Adults over 65 are at risk of memory loss and mental confusion. Some cancer treatments, like chemo, radiation, targeted therapy, or immunotherapy, could make these problems worse. Tell your cancer care team if you are experiencing these symptoms so they can help you manage them.

Thyroid problems are common in people with cancer. When your thyroid doesn’t work correctly, you may feel tired, gain or lose weight, feel cold, or have mood changes. These symptoms can be confusing because they can also be due to cancer or its treatment. If you have thyroid issues, your cancer care team will check your thyroid function with regular blood tests and adjust medicines based on these results.

Autoimmune diseases, like rheumatoid arthritis, lupus, or multiple sclerosis, can make cancer treatment more complex. Cancer treatments can sometimes make autoimmune symptoms worse or interact with the medicines you already take. Always tell your cancer care team if you have any autoimmune conditions and report new or worsening symptoms.

When you go to the dentist during cancer treatment, tell your dental care team about your cancer treatment. This is very important if you have any problems with your mouth or teeth.

If possible, have dental work done before your treatment begins or wait until it is complete. Some people may benefit from seeing an oncologic dentist, a specialist in caring for patients with cancer.

Also, make sure your cancer care team knows about any problems with your mouth or teeth.

Tips for managing other health problems

Many people, especially adults who are 65 and older, have more than one health problem. This can make cancer care and follow-up care more complicated.

If you have multiple health problems, these tips may help:

When you meet your cancer care team or survivorship care team, tell them about your complete medical history. This helps reduce the risk of drug interactions, side effects, and other problems during treatment. Keep your team updated on any changes to your health or other conditions. This includes:

  • Any chronic health problems
  • Your medicines (dose, schedule, and side effects)
  • Medication allergies and reactions
  • Past surgeries or medical procedures
  • Medical tests and results
  • Contact information for your other health care providers

If you have seen any specialists outside your health system, bring copies of those medical records to appointments.

If you have cancer and other health problems, palliative care can offer extra support starting soon after diagnosis and continuing through treatment. Palliative care helps relieve symptoms, improve quality of life, support daily life, and assist with future planning.

The palliative care team focuses on your comfort, health goals, and coordination with your cancer care team.

Continue to see your doctors from before your cancer diagnosis, such as your primary care doctor or specialists. Let them know about your cancer treatment and any new or worsening symptoms.

In the United States, Medicare requires an annual wellness exam to maintain coverage. Even during cancer treatment, it’s important to keep this appointment with your primary care doctor.

When you have multiple health conditions, it’s important to manage all your medicines carefully.

To stay on track:

  • Take all medicines as prescribed and check labels carefully for the correct dose
  • Use a chart, pill calendar, pill case, or phone reminders to track doses
  • Fill all prescriptions at the same pharmacy and bring your medicine list to every appointment
  • Tell your care team about any new medicines, dose changes, or supplements, like vitamins or herbs

Ask your pharmacist how they can help you safely manage your medicines during cancer treatment.

Eating a healthy diet, being physically active, and getting enough sleep can help you feel better when you have cancer and other health problems. These habits help boost the immune system, give you energy, reduce side effects, and support your mental health.

Questions to ask your cancer care team

  • Will any of my other health problems affect my cancer treatment, or vice versa?
  • How will my overall health be monitored during my cancer treatment?
  • Could any of the medicines I am currently taking interact with the medicines I will take during cancer treatment?
  • Will I need to stop any of my current medicines during cancer treatment? If so, will I take another instead?
  • Who should I tell if I develop any new side effects or another health problem? How soon?
  • Who can I talk to if I'm feeling anxious or upset about my health?
  • Do you know of any resources that can help me manage my health problems at home?

side by side logos for American Cancer Society and American Society of Clinical Oncology

Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

Alhuneafat L, Guha A, Blaes A, & Konety SH. Cancer and cardiovascular disease: Shared risk factors, mechanisms, and clinical implications. JACC:Cardiooncology. 2023. 7(5), 453-469.

American Society of Clinical Oncology (ASCO). When cancer is not your only health concern. Accessed from www.cancer.net. Content is no longer available.

Chan R & Nekhlyudov L. Overview of cancer survivorship care for primary care and oncology providers. UpToDate. 2025. Accessed at https://www.uptodate.com/contents/16613#H11934028 on November 24, 2025.

Hill L, Delgado B, Lambrinou E, Mannion T, Harbison M, & McCune C. Risk and management of patients with cancer and heart disease. Cardio Ther. 2023; 12:227-241. doi:10/1007/s40119-023-00305-w

National Cancer Institute (NCI). Cancer prevention overview (PDQ) – patient version. Updated May 2, 2025. Accessed at https://www.cancer.gov/about-cancer/causes-prevention/patient-prevention-overview-pdq on November 24, 2025.

Shahid RK, Ahmed S, Le D, & Yadav S. Diabetes and cancer: Risk, challenges, management and outcomes. Cancers. 2021; 13(22), 5735.

Whitson HE, & Boyd CM. Multiple chronic conditions. UpToDate. 2025. Accessed at https://www.uptodate.com/contents/16526#H30994459 on November 24, 2025.

Zhu B, & Qu S. The relationship between diabetes mellitus and cancer and its underlying mechanisms. Front. Endocrinology. 2022; 13:800995. doi:10.3389/fendo.2022.800995

Last Revised: November 28, 2025

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