Cancer Risk and Prevention

Cancer Facts for Women

Some of the most common cancers in women are breast, lung, colorectal, endometrial, cervical, ovarian, and skin cancers. Knowing what you can do to help prevent these cancers or find them early might help save your life.

Breast cancer

Breast cancer is the most common cancer in women in the US. It's also the second-leading cause of cancer death in women after lung cancer. About 1 in 8 women will get invasive breast cancer in their lifetime.

It can occur at any age, but the risk goes up as you get older. Some women might have a greater chance of having breast cancer than others.

Every woman should know about risk factors for breast cancer, ways to help lower their risk, and breast cancer screening recommendations.

Getting regular screening tests is the best way to find breast cancer early, when treatment is more likely to be successful.

The American Cancer Society recommends the following for women at average risk for breast cancer:

  • Women ages 40 to 44 should have the option to start yearly breast cancer screening with a mammogram (x-ray of the breast).
  • Women ages 45 to 54 should get a mammogram every year.
  • Women 55 and older can switch to a mammogram every 2 years, or can continue yearly screening.

Screening should continue as long as a woman is in good health and is expected to live at least 10 more years.

If you're getting a mammogram for breast cancer screening, you should know:

Women at high risk for breast cancer should begin screening at age 30 with a breast MRI and a mammogram. You might be at high risk if you:

  • Have a BRCA1 or BRCA2 gene mutation or have a parent, brother, sister, or child with these mutations
  • Had radiation therapy to your chest before you were 30 years old
  • Have other inherited gene changes known to increase your risk
  • Have a 20% or greater lifetime risk of breast cancer based on risk assessment tools

Talk with a health care provider about your risk for breast cancer and the best screening plan for you.

Colorectal cancer

Colorectal cancer (CRC) is cancer is the third most common cancer and the fourth-leading cause of cancer-related death in women. Alaska Native people have the highest rates of colorectal cancer and are most likely to die from the disease compared to other racial or ethnic groups.

While colorectal cancer rates are dropping overall, rates in people younger than 50 are rising. Colorectal cancer has now become the most common cause of cancer-related death in this group. 

Some factors that increase colorectal cancer risk include having excess body weight, type 2 diabetes, a diet high in red and processed meats, physical inactivity, smoking, alcohol use, and a personal or family history of colorectal cancer or polyps.

Regular colorectal cancer screening helps prevent colorectal cancer or find it early, when treatment is more likely to be successful.

Most colorectal cancers start with a polyp – a small growth in the colon or rectum. Certain screening tests can remove polyps before they turn into cancer.

The American Cancer Society recommends the following for people at average risk for colorectal cancer:

  • Everyone should start regular screening at age 45.
  • People who are in good health and with a life expectancy of more than 10 years should continue regular colorectal cancer screening through age 75.
  • For people ages 76 to 85, the decision to be screened should be based on a person’s preferences, life expectancy, health, and screening history.
  • People over age 85 should no longer get colorectal cancer screening.

Screening tests for colorectal cancer

Screening can be done either with a stool-based test, which looks for signs of cancer in a person’s stool, or a visual exam, which is an exam that looks at the colon and rectum.

Stool-based tests

Options include:

  • Fecal immunochemical test (FIT)* every year
  • Guaiac-based fecal occult blood test (gFOBT)* every year
  • Stool DNA test with fecal immunochemical testing (MT-sDNA or sDNA-FIT or FIT-DNA) every 3 years*

Visual (structural) exams of the colon and rectum

Options include:

  • Colonoscopy every 10 years
  • CT colonography (virtual colonoscopy)* every 5 years
  • Sigmoidoscopy* every 5 years

*If a person gets screened with a test other than colonoscopy, any abnormal test result should be followed up with colonoscopy.

If you’re at high risk

If you're at high risk of colorectal cancer you might need to start screening before age 45, be screened more often, or get specific tests. You might be at higher risk if you have:

  • A personal history of polyps, colorectal cancer, inflammatory bowel disease, or radiation to your abdomen (belly) or pelvic area 
  • A family history of polyps, colorectal cancer, or a hereditary colorectal cancer syndrome

There are some differences between these tests to consider, but the most important thing is to get screened, no matter which test you choose.

Talk to a health care provider about which tests might be good options for you and to your insurance provider about your coverage. If you don't have insurance or can't afford cancer screening, find free and low-cost screening options.

Lung cancer

Lung cancer is the second most common type of cancer in women in the US and the leading cause of cancer death.

Factors that increase the risk of lung cancer include tobacco use and exposure to secondhand smoke, radon, asbestos, air pollution, and cancer-causing chemicals. Having had previous radiation therapy to your lungs and a personal or family history of lung cancer can also increase your risk.

The American Cancer Society recommends yearly lung cancer screening with a low-dose CT (LDCT) scan for people who:

  • Are ages 50 to 80 years and smoke or used to smoke

AND

  • Have at least a 20 pack-year history of smoking

A pack-year is equal to smoking 1 pack of cigarettes per day for a year. For example, a person could have a 20 pack-year history by smoking 1 pack a day for 20 years or by smoking 2 packs a day for 10 years.

Before deciding to get screened, people should talk to their health care provider about the purpose of screening, how it's done, the benefits, limitations, and possible harms of screening. People who still smoke should be counseled about quitting and offered resources to help them quit.

Smoking tobacco is the leading cause of cancer. If you don’t smoke, don’t start.

If you smoke, takes steps to quit using tobacco. You can also call the American Cancer Society at 1-800-227-2345 or visit Empowered to Quit for help quitting.

Other ways you can help lower your risk:

  • Avoid radon exposure.
  • Stay away from secondhand smoke.
  • Avoid or limit exposure to cancer-causing chemicals at home or in your workplace.

Cervical cancer

Human papillomavirus (HPV) causes almost all cervical cancers. HPV is a very common virus that almost everyone who has had sexual contact has been infected by at least once. However, certain types of HPV can cause cancer.

You might be at increased risk for HPV infection if you:

  • Began having sex at an early age
  • Have had many sexual partners, although infection can happen with only one sexual partner
  • Have a suppressed immune system
  • Had a high number of childbirths
  • Smoke cigarettes

The American Cancer Society recommends all children get the HPV vaccine between the of ages 9 and 12, when the vaccine works best. But teens and young adults should still get the vaccine through age 26.

Vaccination at the recommended ages will help prevent more cancers than vaccination at older ages. If you're between the ages of 27 to 45, talk to your doctor to find out if HPV vaccination might benefit you.

Regular screening can help find:

  • Changes in your cervix that can be treated before they become cancer
  • Cervical cancer in its early stages, when treatment is more likely to be successful

The American Cancer Society recommends the following for people who have a cervix and are at average risk for cervical cancer.

Primary HPV testing

Testing only for HPV infection on a cervical sample collected by your health care provider is the preferred screening option. This test should be done every 5 years. 

Other testing options

Other options for cervical cancer screening include:

Self-collected* HPV testing, every 3 years: For this test, you collect your own sample by inserting a soft swab into your vagina. It can be done privately in a clinic, a doctor’s office, or at home. A health care provider needs to order the test. 

Co-testing, every 5 years: In some places, HPV testing is combined with a Pap test, which is a test that looks at cervical cells under a microscope. Your health care provider collects the cervical sample for this type of testing.

Pap test alone, every 3 years: If none of the other screening tests are an option, you can be screened with a Pap test alone every 3 years. 

*Self-collection should only be done using tests and collection devices approved by the US Food and Drug Administration (FDA). These are only available through your health care provider.

When to stop screening

You can stop screening at age 65 if one of the these applies to you: 

  • You’ve had HPV testing collected by a provider or co-testing every 5 years, and your last 2 tests were normal.
  • You’ve had self-collected HPV testing every 3 years, and your last 2 tests were normal.
  • You’ve had Pap tests every 3 years, and your last 3 Pap tests were normal.
  • You’ve had a total hysterectomy (removal of the uterus and cervix) and don’t have a history of a serious precancer or cervical cancer in the last 25 years.

This guideline applies to you even if:

  • You’ve received the HPV vaccine.
  • You’re in a long-term relationship with the same partner, have stopped having children, do not have sex with men, or are not sexually active.
  • You’re in menopause.

Getting screened regularly is the most important thing, no matter which test you get.

Endometrial cancer

Endometrial cancer starts in the inner lining of the uterus. It is the fourth most common cancer in women.

The risk of endometrial cancer is linked with excess body weight and not being physically active. Other things that increase risk include uterine estrogen exposure from estrogen-only menopause hormonal therapy, late menopause, and polycystic ovarian syndrome. Medical conditions like Lynch syndrome, type 2 diabetes, and tamoxifen treatment for breast cancer can also play a role.   

The American Cancer Society recommends that all women should be told about the risks and symptoms of endometrial cancer at menopause.

There are no screening tests or exams to find endometrial cancer early in women at average risk.  

The most common symptoms of endometrial cancer are abnormal vaginal bleeding or spotting, especially in postmenopausal women. Belly pain, pain while peeing, or pain during sex can also be symptoms.

Let your health care provider know right away if you have any of these symptoms and they might be early symptoms of endometrial cancer.

The American Cancer Society recommends that women who have or might have hereditary non-polyposis colorectal cancer (HNPCC or Lynch syndrome) be offered yearly testing with an endometrial biopsy and/or transvaginal ultrasound starting at age 35.

Ovarian cancer

Ovarian cancer is the 6th leading cause of cancer death in women.

The most important risk factor for ovarian cancer, other than age, is a family history of breast or ovarian cancer. This includes those with inherited gene changes like BRCA1, BRCA2, and Lynch syndrome.

Other things that might increase your risk for ovarian cancer are:

  • Having a personal history of breast cancer, endometriosis, and pelvic inflammatory disease
  • Using estrogen-only menopausal hormone therapy
  • Smoking cigarettes
  • Having excess body weight

Currently, there are no recommended cancer screening tests for ovarian cancer, so it is important to know the signs and symptoms. These can include:

  • Belly swelling with weight loss
  • Gas, bloating, and loss of appetite
  • Back, belly, or pelvic pain
  • Feeling like you need to pee all the time

If you have these symptoms daily for more than a few weeks, talk to your health care provider.

Some women at high risk because of a strong family history or inherited gene changes might consider preventive surgery. If you have an increased risk, talk to your health care provider about whether this might be right for you.

Skin cancer

Skin cancer is the most common type of cancer in the US. People of any skin tone can get skin cancer. It's also one of the easiest cancers to prevent or find early.

Ultraviolet (UV) radiation from the sun causes most skin cancers. Tanning booths and sun lamps also expose you to UV rays that can cause cancer.

Practicing sun safety is one of the most important things you can do to lower your risk of skin cancer:

  • Seek shade and limit time in the sun, especially between 10 a.m. and 4 p.m. when the sun's rays are strongest.
  • Use a broad-spectrum sunscreen with a sun protection factor (SPF) of at least 30 on exposed skin all year round. Reapply sunscreen every 2 hours or after swimming or sweating, even if it's waterproof.
  • Wear protective clothing, sunglasses that have UV protection, and a hat.
  • Avoid tanning beds and sun lamps.

The best way to catch skin cancer early is to check your skin for changes. Many health care providers suggest checking your skin about once a month.

  • Know what the moles and spots on your skin look like and report any changes to a health care provider right away.
  • Ask about having a skin exam done during your regular health checkups.

What else you can do to help reduce your cancer risk

Almost half of all adult cancers might be prevented by things we can do or change. To help keep your cancer risk low:

  • Stay away from tobacco.
  • Be as physically active as you can.
  • Eat a healthy diet, including fruits, vegetables, and whole grains.
  • Avoid or limit highly processed foods, red or processed meats, sugary drinks, and refined grains.
  • Get to and stay at a healthy weight.
  • It’s best not to drink alcohol. If you do drink, have no more than 1 drink per day for women.
  • Protect your skin from the sun.
  • Know yourself, your family history, and your risks.
  • Get regular checkups and recommended cancer screening tests.

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The American Cancer Society medical and editorial content team

Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as editors and translators with extensive experience in medical writing.

American Cancer Society. Breast Cancer Facts and Figures 2024-2025. Atlanta: American Cancer Society; 2024.

American Cancer Society. Cancer Facts & Figures 2026. Atlanta: American Cancer Society; 2026.

American Cancer Society. Cancer Prevention & Early Detection Facts & Figures 2025-2026.  Atlanta: American Cancer Society; 2025.

Centers for Disease Control and Prevention. Cancer and women. Accessed at https://www.cdc.gov/cancer/features/cancer-and-women.html on January 22, 2026.

Fontham ETH, Wolf AMD, Church TR, et al. Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society. CA Cancer J Clin. 2020; 70: 321-346. doi.org/10.3322/caac.21628

Oeffinger KC, Fontham ET, Etzioni R, et al. Breast cancer screening for women at average risk: 2015 guideline update From the American Cancer Society. JAMA. 2015;314(15):1599-1614.

Perkins, R.B., Wolf, A.M.D., Church, T.R., et al. Self‐collected vaginal specimens for human papillomavirus testing and guidance on screening exit: An update to the American Cancer Society cervical cancer screening guideline. CA Cancer J Clin. 2025. Available at https://doi.org/10.3322/caac.70041

Saslow D, Andrews KS, Manassaram-Baptiste D, et al. Human papillomavirus vaccination 2020 guideline update: American Cancer Society guideline adaptation. CA Cancer J Clin. 2020; 70: 273-274. doi 10.3322/caac.21616.

Siegel RL, Wagle NS, Jemal A. Leading Cancer Deaths in People Younger Than 50 Years. JAMA. Published online January 22, 2026. doi:10.1001/jama.2025.25467

Wolf AMD, Fontham ETH, Church TR, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin. 2018;68(4):250-281. doi:10.3322/caac.21457

Wolf, AMD, Oeffinger, KC, Shih, YCT, et al. Screening for lung cancer: 2023 guideline update from the American Cancer Society. CA Cancer J Clin. 2023. doi:10.3322/caac.21811 

Last Revised: February 3, 2026

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