Perfluorooctanoic Acid (PFOA), Perfluorooctane Sulfonate (PFOS), and Related Chemicals

What are PFOA and PFOS?

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are part of a large group of lab-made chemicals known as perfluoroalkyl and polyfluoroalkyl substances (PFAS). Some of these chemicals have been in commercial use since the 1940s.

PFAS are very stable and don’t interact much with other chemicals, so they can be helpful in making products that resist oils, stains, water, and heat. PFAS have been used to make non-stick coatings on cookware, as well as protective coatings for products like carpets and fabrics. They have also been used in coatings for paper and cardboard food packaging, firefighting foams, ski wax, and some other products.

PFAS have the potential to be a health concern because they don’t break down easily and can stay in the environment and in the human body for a long time. Studies have found them worldwide at very low levels in just about everyone’s blood. Higher blood levels have been found in communities where local water supplies have been contaminated by PFAS. People exposed to PFAS in the workplace can have levels many times higher.

Some PFAS, such as PFOA, can be found at low levels in some foods, drinking water, and in household dust. Although the levels in drinking water are usually low, they can be higher in certain areas, such as near industrial plants that have used these chemicals.

Do PFOA and other PFAS cause cancer?

There are many PFAS, but the ones that have been made and used the most in the United States are PFOA and PFOS. While these 2 chemicals are no longer made in the US, people can still be exposed to them (see “What is being done about PFOA and other PFAS?”).

Most of the studies so far that have looked at possible health effects of PFAS have focused on PFOA, mainly because it has been used the most. Many studies have looked at whether PFOA can cause cancer. 

Researchers use 2 main types of studies to try to figure out if a substance might cause cancer.

Studies in the lab

Studies in lab animals have found exposure to PFOA increases the risk of certain tumors of the liver, testicles, mammary glands (breasts), and pancreas. While not always the case, well-conducted studies in animals generally do a good job of predicting which exposures might cause cancer in people, too.

Studies in humans

Studies have looked at cancer rates in people living near or working in PFOA-related chemical plants. Some of these studies have suggested an increased risk of testicular cancer and kidney cancer with increased PFOA exposure. Studies have also suggested a possible link to thyroid cancer, but the increases in risk have been small and could have been due to chance.

Other studies have suggested possible links to other cancers, including prostate, bladder, breast, and ovarian cancer. But not all studies have found such links, and more research is needed to clarify these findings.

What expert agencies say

In most cases, the American Cancer Society does not determine if something causes cancer (that is, if it is a carcinogen). Instead, we look to other respected organizations that classify potentially cancer-causing exposures.

The International Agency for Research on Cancer (IARC) is part of the World Health Organization (WHO). One of its goals is to identify causes of cancer. IARC has classified PFOA as “possibly carcinogenic to humans” (Group 2B), based on limited evidence in humans that it can cause testicular and kidney cancer, and limited evidence that it can cause cancer in lab animals.

(For more information on the classification system IARC uses, see Known and Probable Human Carcinogens.)

The US Environmental Protection Agency (EPA) maintains the Integrated Risk Information System (IRIS), an electronic database that contains information on human health effects from exposure to various substances in the environment. The EPA has not officially classified PFOA as to its carcinogenicity.

In a draft (not final) report, the EPA’s Scientific Advisory Board examined the evidence on PFOA, mainly from studies in lab animals, and stated that there is “suggestive evidence of carcinogenicity, but not sufficient to assess human carcinogenic potential.” The board agreed that new evidence would be considered as it becomes available.

Other agencies have not yet formally evaluated whether PFOA can cause cancer.

To learn more about how cancer causes are studied and classified, see Determining if Something Is a Carcinogen and Known and Probable Human Carcinogens.

What is being done about PFOA and other PFAS?

The long-term health effects of PFAS are still largely unknown, but there has been enough concern to phase out the use of some of them.

For example, PFOA and some closely related chemicals (such as PFOS) are now no longer made in the US, although they are still made in some other countries and could potentially reach US consumers in certain types of products. 

Another potential concern is that other PFAS are now in use. For example, hexafluoropropylene oxide (HFPO, also known as a ‘GenX’ chemical) is often used to replace PFOA in manufacturing processes, while perfluorobutane sulfonic acid (PFBS) is used as a replacement for PFOS. New PFAS also continue to be developed. These chemicals haven’t been around long enough for researchers to fully understand if they might have the same (or even different) health effects.

Drinking water

Drinking water is one of the main sources of PFAS exposure for some people. In the US, the EPA regulates contaminants in public drinking water systems. 

The EPA does not enforce limits on the levels of PFAS in drinking water at this time. However, the EPA has established health advisories for some PFAS in drinking water, based largely on the health effects seen in studies of lab animals (rats and mice). As of June, 2022, there are lifetime health advisory levels for 4 PFAS, in parts per trillion (ppt):

  • PFOA: 0.004 ppt
  • PFOS: 0.02 ppt
  • GenX chemicals: 10 ppt
  • PFBS: 2,000 ppt

These advisories are not legally enforceable federal standards. They are meant to provide drinking water system operators, as well as state and other agencies responsible for overseeing these systems, with information on the health risks of these chemicals, so they can take appropriate actions to protect their residents.

In addition, the EPA is now considering establishing drinking water standards for some PFAS, which, if enacted, would set legally enforceable maximum contaminant levels (MCLs) of these substances in drinking water.

Foods

Food appears to be one of the main sources of exposure to PFAS for many people. This might be from the food itself (depending on where it’s grown), or from the packaging the food comes in. 

In the United States, the Food and Drug Administration (FDA) is responsible for the safety of the food supply. 

The FDA has allowed certain PFAS to be used on paper or paperboard that could come into contact with food, to help prevent grease from going through them. However, due to questions about the possible effects of some of these PFAS on human health, the FDA is working with manufacturers to phase out these PFAS.

In 2019, the FDA began more widespread testing of different foods for the presence of certain PFAS (including PFOA and PFOS). A small percentage of samples have been found to contain low levels of PFAS, mostly in different types of seafood (although many seafood samples did not contain PFAS). However, in 2022 the FDA reported finding higher levels in some canned clams (particularly in some coming from China).

The FDA continues to test different food samples for PFAS and has stated it will use this information to guide its regulatory approach going forward.

Other measures

In 2021, several US government agencies announced new steps to address PFAS in our air, water, and food. This includes the EPA and the FDA, as well as the US Department of Agriculture (USDA), the Department of Health and Human Services (DHHS), and several other agencies. The goal is to take a comprehensive approach to research, regulation, and remediation of PFAS contamination.

Should I take measures to protect myself?

There doesn’t seem to be a way to avoid exposure to PFAS completely, as they can be detected in just about everyone’s blood. But understanding how you might be exposed can help you decide if there are steps you want to take that might lower your exposure.

Non-stick cookware: Other than the possible risk of flu-like symptoms from breathing in fumes from heated cookware with non-stick coatings, there are no proven risks to humans from using these products. While PFAS can be used in making some of these coatings, it is not present (or is present in extremely small amounts) in the final products.

Foods: As noted above, the FDA has detected PFAS in some seafood samples, particularly in some canned clams. For people wondering if they should change what they eat because of this, the FDA still recommends eating a variety of age-appropriate healthy foods, including seafood. Seafood as a part of a healthy diet can provide many nutritional benefits for both children and adults. According to the FDA, people who regularly eat canned clams from China may want to reduce their overall intake until more information becomes available.

Drinking water: Drinking water is a main source of exposure for people in communities with contaminated water. According to the US Centers for Disease Control and Prevention (CDC), people whose regular source of drinking water is found to have higher than normal levels of PFOA or similar chemicals might consider using bottled water or installing activated carbon water filters. If you do not know if your water is contaminated, ask your local health department.

Can I be tested for PFAS exposure?

For people who are concerned they might have been exposed to high levels of PFOA or other PFAS, blood levels can be measured, but this is not a routine test that can be done in a doctor’s office. Even if the test is done, it’s not yet clear what the results might mean in terms of possible health effects.

Still, if you have reason to be concerned about your exposure, such as having worked or lived in a place where PFAS exposure was likely, talk to your doctor to learn more about testing and what the results might mean for your health.

The American Cancer Society medical and editorial content team

Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Along with the American Cancer Society, other sources of information include:

Agency for Toxic Substances and Disease Registry (ATSDR) (part of the CDC)
Toll-free number: 1-888-422-8737 (1-888-42-ATSDR)
Website: www.atsdr.cdc.gov
ToxFAQs for perfluoroalkyls: www.atsdr.cdc.gov/toxfaqs/tf.asp?id=1116&tid=237
FAQ Fact Sheet: www.atsdr.cdc.gov/pfas/docs/pfas_fact_sheet.pdf
Per- and Polyfluoroalkyl Substances (PFAS) and Your Health: www.atsdr.cdc.gov/pfas/index.html

Environmental Protection Agency (EPA)
Toll-free number (Safe Drinking Water Hotline): 1-800-426-4791
Website: www.epa.gov
Per- and Polyfluoroalkyl Substances (PFAS): www.epa.gov/pfas

Food and Drug Administration (FDA)
Toll-free number: 1-888-INFO-FDA (1-888-463-6332)
Website: www.fda.gov
Questions and Answers on PFAS in Food: www.fda.gov/food/chemical-contaminants-food/questions-and-answers-pfas-food

*Inclusion on this list does not imply endorsement by the American Cancer Society.

No matter who you are, we can help. Contact us anytime, day or night, for information and support. Call us at 1-800-227-2345 or visit www.cancer.org.

Agency for Toxic Substances and Disease Registry. ToxFAQs for perfluoroalkyls. 2021. Accessed at https://wwwn.cdc.gov/TSP/ToxFAQs/ToxFAQsDetails.aspx?faqid=1116&toxid=237 on June 16, 2022.

Agency for Toxic Substances and Disease Registry. Per- and Polyfluoroalkyl Substances (PFAS) and Your Health. 2020. Accessed at https://www.atsdr.cdc.gov/pfas/index.html on June 23, 2022.

Barry V, Winquist A, Steenland K. Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant. Environ Health Perspect. 2013;121:1313−1318.

Environmental Protection Agency. Drinking Water Health Advisories for PFAS: Fact Sheet for Communities. 2022. Accessed at https://www.epa.gov/system/files/documents/2022-06/drinking-water-ha-pfas-factsheet-communities.pdf on June 22, 2022.

Environmental Protection Agency. Health Effects Document for Perfluorooctanoic Acid (PFOA). 2014. Accessed at https://nepis.epa.gov/Exe/ZyNET.exe/P100IRZ1.txt?ZyActionD=ZyDocument&Client=EPA&Index=2011%20Thru%202015&Docs=&Query=&Time=&EndTime=&SearchMethod=1&TocRestrict=n&Toc=&TocEntry=&QField=&QFieldYear=&QFieldMonth=&QFieldDay=&UseQField=&IntQFieldOp=0&ExtQFieldOp=0&XmlQuery=&File=D%3A%5CZYFILES%5CINDEX%20DATA%5C11THRU15%5CTXT%5C00000010%5CP100IRZ1.txt&User=ANONYMOUS&Password=anonymous&SortMethod=h%7C-&MaximumDocuments=1&FuzzyDegree=0&ImageQuality=r75g8/r75g8/x150y150g16/i425&Display=hpfr&DefSeekPage=x&SearchBack=ZyActionL&Back=ZyActionS&BackDesc=Results%20page&MaximumPages=1&ZyEntry=1 on June 22, 2022.

Fenton SE, Ducatman A, Boobis A, et al. Per- and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research. Environ Toxicol Chem. 2021;40(3):606-630.

Food and Drug Administration. Authorized Uses of PFAS in Food Contact Applications. 2022. Accessed at https://www.fda.gov/food/chemical-contaminants-food/authorized-uses-pfas-food-contact-applications on July 28, 2022.

Food and Drug Administration. FDA Shares Results on PFAS Testing in Seafood. 2022. Accessed at https://www.fda.gov/food/cfsan-constituent-updates/fda-shares-results-pfas-testing-seafood on July 7, 2022.

Food and Drug Administration. Questions and Answers on PFAS in Food. 2022. Accessed at https://www.fda.gov/food/chemical-contaminants-food/questions-and-answers-pfas-food on June 23, 2022.

International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 110: Some Chemicals Used as Solvents and in Polymer Manufacture. 2017. Accessed at https://publications.iarc.fr/547 on June 16, 2022.

National Academies of Sciences, Engineering, and Medicine. 2022. Guidance on PFAS Exposure, Testing, and Clinical Follow-Up. Washington, DC: The National Academies Press. Accessed at https://nap.nationalacademies.org/catalog/26156/guidance-on-pfas-exposure-testing-and-clinical-follow-up on July 28, 2022.

Post GB, Cohn PD, Cooper KR. Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: A critical review of recent literature. Environ Res. 2012;116:93−117.

Shearer J, Callahan CL, Calafat AM, et al. Serum concentrations of per- and polyfluoroalkyl substances and risk of renal cell carcinoma. J Natl Cancer Inst. 2021;113(5):580-587.

Steenland K, Woskie S. Cohort mortality study of workers exposed to perfluorooctanoic acid. Am J Epidemiol. 2012;176:909–917.

Steenland K, Zhao L, Winquist A. A cohort incidence study of workers exposed to perfluorooctanoic acid (PFOA). Occup Environ Med. 2015;72:373−380.

Steenland K, Winquist A. PFAS and cancer, a scoping review of the epidemiologic evidence. Environ Res. 2021;194:110690.

Sunderland EM, Hu XC, Dassuncao C, et al. A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects. J Expo Sci Environ Epidemiol. 2019;29(2):131-147.

Vieira VM, Hoffman K, Shin HM, et al. Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: A geographic analysis. Environ Health Perspect. 2013;121:318–323.

Additional resources

Along with the American Cancer Society, other sources of information include:

Agency for Toxic Substances and Disease Registry (ATSDR) (part of the CDC)
Toll-free number: 1-888-422-8737 (1-888-42-ATSDR)
Website: www.atsdr.cdc.gov
ToxFAQs for perfluoroalkyls: www.atsdr.cdc.gov/toxfaqs/tf.asp?id=1116&tid=237
FAQ Fact Sheet: www.atsdr.cdc.gov/pfas/docs/pfas_fact_sheet.pdf
Per- and Polyfluoroalkyl Substances (PFAS) and Your Health: www.atsdr.cdc.gov/pfas/index.html

Environmental Protection Agency (EPA)
Toll-free number (Safe Drinking Water Hotline): 1-800-426-4791
Website: www.epa.gov
Per- and Polyfluoroalkyl Substances (PFAS): www.epa.gov/pfas

Food and Drug Administration (FDA)
Toll-free number: 1-888-INFO-FDA (1-888-463-6332)
Website: www.fda.gov
Questions and Answers on PFAS in Food: www.fda.gov/food/chemical-contaminants-food/questions-and-answers-pfas-food

*Inclusion on this list does not imply endorsement by the American Cancer Society.

No matter who you are, we can help. Contact us anytime, day or night, for information and support. Call us at 1-800-227-2345 or visit www.cancer.org.

References

Agency for Toxic Substances and Disease Registry. ToxFAQs for perfluoroalkyls. 2021. Accessed at https://wwwn.cdc.gov/TSP/ToxFAQs/ToxFAQsDetails.aspx?faqid=1116&toxid=237 on June 16, 2022.

Agency for Toxic Substances and Disease Registry. Per- and Polyfluoroalkyl Substances (PFAS) and Your Health. 2020. Accessed at https://www.atsdr.cdc.gov/pfas/index.html on June 23, 2022.

Barry V, Winquist A, Steenland K. Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant. Environ Health Perspect. 2013;121:1313−1318.

Environmental Protection Agency. Drinking Water Health Advisories for PFAS: Fact Sheet for Communities. 2022. Accessed at https://www.epa.gov/system/files/documents/2022-06/drinking-water-ha-pfas-factsheet-communities.pdf on June 22, 2022.

Environmental Protection Agency. Health Effects Document for Perfluorooctanoic Acid (PFOA). 2014. Accessed at https://nepis.epa.gov/Exe/ZyNET.exe/P100IRZ1.txt?ZyActionD=ZyDocument&Client=EPA&Index=2011%20Thru%202015&Docs=&Query=&Time=&EndTime=&SearchMethod=1&TocRestrict=n&Toc=&TocEntry=&QField=&QFieldYear=&QFieldMonth=&QFieldDay=&UseQField=&IntQFieldOp=0&ExtQFieldOp=0&XmlQuery=&File=D%3A%5CZYFILES%5CINDEX%20DATA%5C11THRU15%5CTXT%5C00000010%5CP100IRZ1.txt&User=ANONYMOUS&Password=anonymous&SortMethod=h%7C-&MaximumDocuments=1&FuzzyDegree=0&ImageQuality=r75g8/r75g8/x150y150g16/i425&Display=hpfr&DefSeekPage=x&SearchBack=ZyActionL&Back=ZyActionS&BackDesc=Results%20page&MaximumPages=1&ZyEntry=1 on June 22, 2022.

Fenton SE, Ducatman A, Boobis A, et al. Per- and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research. Environ Toxicol Chem. 2021;40(3):606-630.

Food and Drug Administration. Authorized Uses of PFAS in Food Contact Applications. 2022. Accessed at https://www.fda.gov/food/chemical-contaminants-food/authorized-uses-pfas-food-contact-applications on July 28, 2022.

Food and Drug Administration. FDA Shares Results on PFAS Testing in Seafood. 2022. Accessed at https://www.fda.gov/food/cfsan-constituent-updates/fda-shares-results-pfas-testing-seafood on July 7, 2022.

Food and Drug Administration. Questions and Answers on PFAS in Food. 2022. Accessed at https://www.fda.gov/food/chemical-contaminants-food/questions-and-answers-pfas-food on June 23, 2022.

International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 110: Some Chemicals Used as Solvents and in Polymer Manufacture. 2017. Accessed at https://publications.iarc.fr/547 on June 16, 2022.

National Academies of Sciences, Engineering, and Medicine. 2022. Guidance on PFAS Exposure, Testing, and Clinical Follow-Up. Washington, DC: The National Academies Press. Accessed at https://nap.nationalacademies.org/catalog/26156/guidance-on-pfas-exposure-testing-and-clinical-follow-up on July 28, 2022.

Post GB, Cohn PD, Cooper KR. Perfluorooctanoic acid (PFOA), an emerging drinking water contaminant: A critical review of recent literature. Environ Res. 2012;116:93−117.

Shearer J, Callahan CL, Calafat AM, et al. Serum concentrations of per- and polyfluoroalkyl substances and risk of renal cell carcinoma. J Natl Cancer Inst. 2021;113(5):580-587.

Steenland K, Woskie S. Cohort mortality study of workers exposed to perfluorooctanoic acid. Am J Epidemiol. 2012;176:909–917.

Steenland K, Zhao L, Winquist A. A cohort incidence study of workers exposed to perfluorooctanoic acid (PFOA). Occup Environ Med. 2015;72:373−380.

Steenland K, Winquist A. PFAS and cancer, a scoping review of the epidemiologic evidence. Environ Res. 2021;194:110690.

Sunderland EM, Hu XC, Dassuncao C, et al. A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects. J Expo Sci Environ Epidemiol. 2019;29(2):131-147.

Vieira VM, Hoffman K, Shin HM, et al. Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: A geographic analysis. Environ Health Perspect. 2013;121:318–323.

Last Revised: July 28, 2022

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